Family Wellness DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE 2 g/100g; .1 g/100g Cream
by FRONT PHARMACEUTICAL PLC · 1 TUBE in 1 BOX (69571-005-02) / 28 g in 1 TUBE (69571-005-01)
NDC 69571-0005-02
🏷️ FDA NDC (as labeled)
69571-005-02
billing pads the product segment with a zero
OTC
On market
Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →
🆔 Identity & classification
FDA NDC (as labeled)
69571-005-02
Product NDC
69571-005
11-digit billing NDC
69571000502
RxCUI
1087026
UNII
TC2D6JAD40, FM5526K07A
UPC
0032251071829
Application #
M017
SPL Set ID
fde2069b-344e-46da-bb95-c5113e0f35d6
Established class (EPC)
Copper Absorption Inhibitor; Histamine-1 Receptor Antagonist
Mechanism of action
Histamine H1 Receptor Antagonists
Physiologic effect
Decreased Copper Ion Absorption
DEA schedule
Non-controlled
Marketing category
OTC MONOGRAPH DRUG
Marketing status
On market
FDA listing status
Listed (active directory)
Marketing start
2017-03-29
Route
TOPICAL
Dosage form
CREAM
Substance
DIPHENHYDRAMINE HYDROCHLORIDE; ZINC ACETATE
Why two NDCs?
The FDA registers this code as 69571-005-02 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 69571-0005-02. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.
🏷️ RxNorm drug class
This medicine belongs to the Histamine-1 Receptor Antagonist class.
Pharmacologic class
Histamine-1 Receptor Antagonist
Drug family (ATC)
Propionic acid derivatives, Antihistamines for topical use, Aminoalkyl ethers
How it works
Histamine H1 Receptor Antagonists
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.
🏭 Manufacturer & labeler
LabelerFRONT PHARMACEUTICAL PLC
FDA applicationM017 (OTC MONOGRAPH DRUG)
Labeler code69571
First marketedMar 2017
Product typeHuman Otc Drug
Portfolio17 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.
🩺 Clinical
📖 About the active ingredient: Diphenhydramine Hydrochloride; Zinc Acetate MedlinePlus · NLM
General information about the ingredient itself — the description of this specific product follows below.
Diphenhydramine is used to treat allergy and cold symptoms: sneezing runny nose red, itchy, watery eyes itching of the nose or throat Diphenhydramine is also used to treat insomnia (difficulty falling asleep or staying asleep) in adults, but should not be used to make a child sleepy. Diphenhydramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Diphenhydramine is also available in combination with other medications. This monograph only includes information about the use of diphenh...
Read the full MedlinePlus article ↗🧪 What is this product?
This is an over-the-counter topical cream marketed under FDA's monograph rules for OTC drugs. It contains diphenhydramine hydrochloride, a first-generation antihistamine, and zinc acetate. Diphenhydramine is commonly used in creams to help reduce itching and skin irritation, while zinc acetate is typically included for its astringent and skin-soothing properties. The cream is applied directly to the skin.
Patient education
Supplement & herbal interactions
1
Nutrient depletion considerations
Diphenhydramine Hydrochloride, Naproxen Sodium may be associated with lower levels of 1 nutrient — worth a chat with your pharmacist, not a cause for alarm.
An association is not a deficiency. Educational only — don't start or stop anything without professional guidance.
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.
💬 Questions about DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE?
Ask a pharmacist →
Ask a licensed pharmacist directly — free, answered by our team.
🧪 Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured
IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.
💲 Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per g | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.
🔁 Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| good sense itch relief 2 g/100g; .1 g/100g 00113-0622-64 | L. | 1 tube | $0.057 | — | Availability likely | — |
| Banophen 2 g/100g; .1 g/100g 00904-5354-31 | Major | 1 tube | $0.057 | — | Availability likely | — |
| diphenhydramine hcl and zinc acetate 2 g/100g; .1 g/100g 45802-0358-03 | Padagis | 1 tube | $0.057 | — | Availability likely | — |
| GNP Extra Strength Anti-Itch Cream .1 g/100g; 2 g/100g 46122-0804-36 | Amerisource | 1 tube | $0.057 | — | Availability likely | — |
| leader anti itch 2 g/100g; .1 g/100g 70000-0388-01 | Cardinal | 1 tube | $0.057 | — | Availability likely | — |
| foster and thrive anti itch cream 2 g/100g; .1 g/100g 70677-1289-01 | Strategic | 1 tube | $0.057 | — | Availability likely | — |
| Anti-Itch 20 mg/g; 1 mg/g 24385-0210-03 | Amerisource | 1 tube | $0.130 | — | Discontinued | — |
| Diphenhydramine Hydrochloride and Zinc Acetate 20 mg/g; 1 mg/g 70677-1213-01 | STRATEGIC | 1 tube | $0.130 | — | FDA listed | — |
| Walgreens Anti Itch Cream 20 mg/g; 1 mg/g 00363-2315-28 | Walgreens | 1 tube | — | — | FDA listed | — |
| Dr. Sheffield Anti Itch Cream 20 mg/g; 1 mg/g 11527-0069-04 | Sheffield | 1 tube | — | — | FDA listed | — |
| Anti-itch 20 mg/g; 1 mg/g 11673-0895-28 | Target | 1 tube | — | — | FDA listed | — |
| Rite Aid Extra Strength Itch Stopping 1 mg/g; 20 mg/g 11822-6614-01 | Rite | 1 tube | — | — | FDA listed | — |
| signature care itch relief 2 g/100g; .1 g/100g 21130-0154-64 | Safeway | 1 tube | — | — | FDA listed | — |
| anti itch 2 g/100g; .1 g/100g 30142-0582-64 | Kroger | 1 tube | — | — | FDA listed | — |
| Shopko Anti-Itch 20 mg/g; 1 mg/g 37012-0089-02 | Shopko | 1 tube | — | — | FDA listed | — |
| itch relief 2 g/100g; .1 g/100g 37808-0622-64 | H | 1 tube | — | — | FDA listed | — |
| Anti-Itch Cream 1 mg/g; 20 mg/g 41226-0888-02 | Kroger | 1 tube | — | — | FDA listed | — |
| Anti Itch 2 g/100g; .1 g/100g 41250-0622-64 | Meijer | 1 tube | — | — | FDA listed | — |
| Equate Anti Itch 2 g/100g; .1 g/100g 49035-0622-64 | Wal-Mart | 1 tube | — | — | FDA listed | — |
| Diphenhydramine Hydrochloride and Zinc Acetate 20 mg/g; 1 mg/g 51672-2089-02 | Sun | 1 tube | — | — | FDA listed | — |
| CAREALL Anti-Itch 20 mg/g; 1 mg/g 51824-0088-01 | New | 35 g | — | — | FDA listed | — |
| Extra Strength Itch Stopping 20 mg/g; 1 mg/g 52000-0071-02 | Universal | 1 tube | — | — | FDA listed | — |
| Discount Drug Mart Extra Strength Itch Stopping 20 mg/g; 1 mg/g 53943-0258-01 | Discount | 1 tube | — | — | FDA listed | — |
| Family Wellness 2 g/100g; .1 g/100g 55621-0007-01 | Zhejiang | 1 tube | — | — | FDA listed | — |
| ItchZap 20 mg/g; 1 mg/g 57237-0352-28 | Rising | 1 tube | — | — | FDA listed | — |
| Itch Relief 2 g/100g; .1 g/100g 59779-0708-64 | CVS | 1 tube | — | — | FDA listed | — |
| Itch Relief Cream 2 g/100g; .1 g/100g 68016-0163-01 | Pharmacy | 1 tube | — | — | FDA listed | — |
| Anti-Itch Cream 2 g/100g; .1 g/100g 69396-0025-05 | Trifecta | 1 tube | — | — | FDA listed | — |
| Itch stopping Cream 2 g/100g; .1 g/100g 69396-0150-01 | Trifecta | 1 tube | — | — | FDA listed | — |
| itch relief 1 mg/g; 20 mg/g 69452-0449-37 | Bionpharma | 1 tube | — | — | FDA listed | — |
| Family Wellness 2 g/100g; .1 g/100gthis 69571-0005-02 | FRONT | 1 tube | — | — | FDA listed | — |
| CVS Extra Strength Itch Stopping 20 mg/g; 1 mg/g 69842-0321-28 | CVS | 1 tube | — | — | FDA listed | — |
| Benadryl Extra Strength Itch Stopping 20 mg/g; 1 mg/g 69968-0223-01 | Kenvue | 1 tube | — | — | FDA listed | — |
| TheraCare 2% Diphenhydramine Anti-Itch Cream 20 mg/g; 1 mg/g 71101-0014-01 | Veridian | 1 tube | — | — | FDA listed | — |
| Caring Mill Anti-Itch Cream 20 mg/g; 1 mg/g 71101-0055-01 | Veridian | 1 tube | — | — | FDA listed | — |
| Anti-Itch Cream 2 g/100g; .1 g/100g 83324-0039-01 | Chain | 1 tube | — | — | FDA listed | — |
| Savvy Itch Stopping 2 g/100g; .1 g/100g 83650-0102-01 | Savvy | 35.4 g | — | — | FDA listed | — |
| topcare anti itch 2 g/100g; .1 g/100g 36800-0622-64 | Topco | 1 tube | — | — | FDA listed | — |
| Itch Stopping 2 g/100g; .1 g/100g 42507-0622-64 | HyVee | 1 tube | — | — | FDA listed | — |
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.
⏳ Availability & generic status
🏛️
2017
On the market since
Mar 2017
📍
2026
Currently FDA-listed
9 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.
🔬 Reported adverse events (FAERS)
Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE — the ingredient across all brands.
Top reported reactions
Reporter sex
Male · 31%
Female · 69%
Serious outcomes
Reports over time (by year) — tap or hover for the count & year
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.
📦 Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Status |
|---|---|---|---|
| 69571-0005-02 You're viewing this | 1 TUBE in 1 BOX (69571-005-02) / 28 g in 1 TUBE (69571-005-01) | 2017-03-29 | Active |
🧭 About this NDC listing & data coverage
Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | ✓ Available |
| Inactive ingredients (structured) | — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available. |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope. |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.
Questions about this listing
Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 69571-005-02, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 69571-0005-02, written without dashes as 69571000502. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 69571-0005-02, the first segment (69571) is the labeler code FDA assigned to FRONT PHARMACEUTICAL PLC; the middle segment (0005) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (02) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by FRONT PHARMACEUTICAL PLC. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
FRONT PHARMACEUTICAL PLC is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
📄 FDA label — Drug Facts FDA SPL
The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage
⏱️ Dosage and Administration
⚠️ Warnings
🧪 Active Ingredient
🧪 Inactive Ingredients
🎯 Purpose
🎯 Indications and Usage ▾
for temprary relief from pain and itching associated Uses with insect bites , sunburn and mior skin irritations. Dries the oozing and weeping of poison: •ivy •oak •sumac
⏱️ Dosage and Administration ▾
Directions •for adults and children over 2 years of age: apply to affected area not more than 3 to 4 times daily •children under 2 years of age: ask a doctor before use
⚠️ Warnings ▾
Warnings . For external use only Do not use •avoid contact with eyes When using this product Ask a doctor before use •on chicken pox •on measles Stop use and ask a doctor if over large areas of the body with any other product containing diphenhydramine including those taken orally symptoms last for more than 7 days the condition gets worse symptoms clear up and then occur again within a few days
🧪 Active Ingredient ▾
Active Ingredients Diphenhydramine hydrochloride 2% Zinc acetate 0.1%
🧪 Inactive Ingredients ▾
cetyl alcohol, glyceryl stearate se, Inactive ingredients laureth-23, methylparaben, mineral oil, petrolatum, propylene glycol, propylparaben, stearic acid, stearic alcohol, water
🎯 Purpose ▾
Purpose Topical analgesic Skin protectant
No label section mentions that — try another word, or open the full label on DailyMed below.
Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA.
Prefer the government’s original formatting? View this label on DailyMed ↗
For educational and professional reference only — not medical advice. Pricing reflects published
NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.