Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.
Itch Relief Diphenhydramine HCl and Zinc Acetate 1.5 g/76g; .076 g/76g Aerosol, Spray, 76 g — NDC 69842-235-27 (Billing 69842-0235-27)
by CVS Pharmacy · 76 g in 1 CANISTER
This is a package of 76 g of Itch Relief Diphenhydramine HCl and Zinc Acetate 1.5 g/76g; .076 g/76g Aerosol, Spray from CVS Pharmacy, marketed since Feb 2019 and currently FDA-listed. It is this product's only package size.
NDC 69842-0235-27
🏷️ FDA NDC (as labeled)
69842-235-27
billing pads the product segment with a zero
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →
NDC database record
One package, one record: these facts belong to NDC 69842-235-27 alone.
- Record
- FDA NDC Directory package listing · Human OTC drug
- Code segments
- 69842 labeler · 235 product · 27 package
- Package marketed since
- Feb 1, 2019
- Sample package
- No — commercial package
- Listing certified through
- Dec 31, 2027
- Billing quantity
- 76 g per package
- Barcode (UPC-A, from the NDC)
- 3 6984223527 9
- FDA record last changed
- Jul 24, 2026
Identity & classification
Regulatory identifiers FDA, NLM and CMS codes for this package
FDA NDC (as labeled)
69842-235-27
Product NDC
69842-235
11-digit billing NDC
69842023527
NCPDP billing unit
GM — per gram (weight)
RxCUI
1053138
UNII
TC2D6JAD40, FM5526K07A
Application #
M017
SPL Set ID
7e921988-ec66-38dc-e053-2a91aa0a7346
Established class (EPC)
Copper Absorption Inhibitor; Histamine-1 Receptor Antagonist
Mechanism of action
Histamine H1 Receptor Antagonists
Physiologic effect
Decreased Copper Ion Absorption
DEA schedule
Non-controlled
Marketing category
OTC MONOGRAPH DRUG
Marketing status
On market
FDA listing status
Listed (active directory)
Marketing start
2019-02-01
Route
TOPICAL
Dosage form
AEROSOL, SPRAY
Substance
DIPHENHYDRAMINE HYDROCHLORIDE; ZINC ACETATE
Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification
GPI-14
90209902080920
GPI class
CVS Itch Relief
GCN Seq No
064776
GCN
16266
HICL code
009759
Ingredient (HICL)
Diphenhydramine Hcl/Zinc Acet
HIC1 code
L
Therapeutic class — broad (HIC1)
Skin/Subcutaneous Tissue
HIC2 code
L3
Therapeutic class — intermediate (HIC2)
Protectives
HIC3 code
L3P
Therapeutic class — specific (HIC3)
Antipruritics,Topical
AHFS code
84:08.00.00
AHFS class
Antipruritics And Local Anesthetics
FDB label name
CVS ITCH RELIEF 2%-0.1% SPRAY
FDB brand name
Itch Relief
Legend status
O — Over-the-counter (OTC) drug or device
Quick answers
- GSN (GCN sequence number): 064776
- GCN: 16266
- GPI-14 (Medi-Span): 90209902080920
- HICL (First Databank): 009759
- AHFS class code: 84:08.00.00
- RxCUI (RxNorm): 1053138
Why two NDCs?
The FDA registers this code as 69842-235-27 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 69842-0235-27. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 5, 2026
- RxNorm (NLM RxNav) · catalog refreshed Oct 1, 2026
- Medi-Span GPI (licensed)
- First Databank (licensed) · refreshed Oct 1, 2026
RxNorm drug class
This medicine belongs to the Histamine-1 Receptor Antagonist class.
Pharmacologic class
Histamine-1 Receptor Antagonist
Drug family (ATC)
Propionic acid derivatives, Antihistamines for topical use, Aminoalkyl ethers
How it works
Histamine H1 Receptor Antagonists
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.
- RxClass (NLM) · catalog refreshed Oct 1, 2026
Clinical
Label name CVS ITCH RELIEF 2%-0.1% SPRAY Ingredient Diphenhydramine Hcl/Zinc Acet
📖 About the active ingredient: Diphenhydramine Hydrochloride; Zinc Acetate MedlinePlus · NLM
General information about the ingredient itself — the description of this specific product follows below.
Diphenhydramine is used to treat allergy and cold symptoms: sneezing runny nose red, itchy, watery eyes itching of the nose or throat Diphenhydramine is also used to treat insomnia (difficulty falling asleep or staying asleep) in adults, but should not be used to make a child sleepy. Diphenhydramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Diphenhydramine is also available in combination with other medications. This monograph only includes information about the use of diphenh...
Read the full MedlinePlus article ↗🧪 What is this product?
This is a topical aerosol spray marketed as an over-the-counter monograph product for itch relief. It contains diphenhydramine hydrochloride, an antihistamine commonly used to reduce itching and minor skin irritation, and zinc acetate, an astringent mineral salt typically included in itch-relief products. The spray is applied directly to the skin surface and is intended for temporary relief of minor itching associated with insect bites, hives, or other minor skin conditions.
Patient education
Supplement & herbal interactions
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.
- MedlinePlus (NLM) · refreshed Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 5, 2026
💬 Questions about Diphenhydramine HCl and Zinc Acetate?
Ask a pharmacist →
Ask a licensed pharmacist directly — free, answered by our team.
Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per mL | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.
- CMS NADAC weekly file
- CMS ASP pricing files · refreshed Sep 20, 2026
- CMS Medicaid State Drug Utilization Data · refreshed Oct 5, 2026
- CMS Part D plan pricing files · refreshed Sep 24, 2026
- VA National Acquisition Center price file
Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Marketing end | Status |
|---|---|---|---|---|
| 69842-0235-27 You're viewing this Main listing | 76 g in 1 CANISTER | 2019-02-01 | — | Active |
Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Good neighbor Pharmacy Itch Relief .1 g/100mL; 2 g/100mL 46122-0572-46 | AMERISOURCEBERGEN | 59 ml | $0.047 | — | Availability likely | — |
| Itch Relief 20 mg/mL; 1 mg/mL 70000-0023-01 | Cardinal | 59 ml | $0.047 | — | Availability likely | — |
| Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 00363-0215-76 | Walgreen | 76 g | — | — | FDA listed | — |
| Extra Strength Wal-Dryl Itch Relief 20 mg/mL; 1 mg/mL 00363-2177-00 | WALGREEN | 88 ml | — | — | FDA listed | — |
| Rite Aid Itch Relief 2 g/100g; .1 g/100g 11822-0647-02 | Rite | 59 g | — | — | FDA listed | — |
| Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 30142-0134-27 | Kroger | 76 g | — | — | Discontinued | — |
| Diphenhydramine HCl and Zinc Acetate 1.5 g/76g; .075 g/76g 36800-0126-76 | Topco | 76 g | — | — | FDA listed | — |
| Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 37808-0526-27 | HEB | 76 g | — | — | FDA listed | — |
| Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 41250-0058-30 | Meijer | 76 g | — | — | FDA listed | — |
| Itch Relief 20 mg/mL; 1 mg/mL 41250-0295-20 | Meijer, | 59 ml | — | — | FDA listed | — |
| Itch Relief 1 mg/g; 20 mg/g 42507-0986-76 | HY-VEE, | 76 g | — | — | FDA listed | — |
| Diphenhydramine HCl and Zinc Acetate 1.5 g/88mL; .075 g/88mL 49035-0015-03 | Wal-Mart | 88 ml | — | — | FDA listed | — |
| GoodSense Anti-Itch 2 g/100mL; .1 g/100mL 50804-0064-02 | Geiss, | 59 ml | — | — | FDA listed | — |
| Itch Relief 20 mg/mL; 1 mg/mL 55910-0295-20 | Old | 59 ml | — | — | FDA listed | — |
| Itch Relief 1 mg/mL; 20 mg/mL 59450-0295-20 | The | 59 ml | — | — | FDA listed | — |
| Quality Choice Itch Relief .1 g/100mL; 2 g/100mL 63868-0952-02 | Chain | 59 ml | — | — | FDA listed | — |
| Best Choice Itch Relief .1 g/100mL; 2 g/100mL 63941-0259-02 | Valu | 59 ml | — | — | FDA listed | — |
| Itch Relief 1.5 g/76g; .076 g/76gthis 69842-0235-27 | CVS | 76 g | — | — | FDA listed | — |
| CVS Itch Relief .1 g/100mL; 2 g/100mL 69842-0952-02 | CVS | 59 ml | — | — | FDA listed | — |
| Benadryl Extra Strength Itch Cooling 20 mg/mL; 1 mg/mL 69968-0270-02 | Kenvue | 59 ml | — | — | FDA listed | — |
| Itch Relief 20 mg/mL; 1 mg/mL 72476-0295-20 | Retail | 059 l | — | — | Discontinued | — |
| Warrior First Aid Anti Itch 2 g/100mL; .1 g/100mL 72839-0647-02 | Derma | 59 ml | — | — | FDA listed | — |
| Extra Strength Itch Relief 20 mg/g; 1 mg/g 79481-0598-01 | Meijer | 76 g | — | — | FDA listed | — |
| Westlake Itch Relief .1 g/100mL; 2 g/100mL 82895-0715-60 | Westlake | 59 ml | — | — | FDA listed | — |
| Extra Strength Itch Relief 20 mg/g; 1 mg/g 83324-0302-27 | Chain | 76 g | — | — | FDA listed | — |
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA Orange Book · refreshed Oct 3, 2026
- CMS NADAC weekly file
Availability & generic status
🏛️
2019
On the market since
Feb 2019
📍
2026
Currently FDA-listed
7 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.
- FDA Orange Book · refreshed Oct 3, 2026
Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
-
UNII 3K9958V90M
A liquid solvent derived from fermentation or chemical synthesis. In medicines, alcohol dissolves active ingredients, helps preserve the product, and improves how the body absorbs certain drugs.
-
UNII ZY81Z83H0X
Aloe vera leaf is a plant extract derived from the aloe plant. It is used in medicines as a natural moisturizer and skin-soothing agent in topical formulations.
-
UNII PDC6A3C0OX
Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
-
UNII 023C2WHX2V
Tromethamine is a chemical buffer that helps maintain the proper acidity level in liquid medicines. It neutralizes acids and stabilizes the solution so the medication remains effective and safe throughout its shelf life.
-
UNII 059QF0KO0R
Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
5 inactive ingredients listed in the exact product block matched to this NDC.
The official label also statesaloe barbadensis leaf juice, glycerin, purified water, SD alcohol 40-B, tromethamine
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed —
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.- FDA label on DailyMed · label index refreshed Oct 5, 2026
- FDA openFDA NDC Directory · synced Oct 1, 2026
Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.
Manufacturer & labeler
LabelerCVS Pharmacy
FDA applicationM017 (OTC MONOGRAPH DRUG)
Labeler code69842
First marketedFeb 2019
Product typeHuman Otc Drug
Portfolio550 products on file
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- Stomach Relief Maximum Strength Bismuth subsalicylate 525 mg/15mL Liquid NDC 69842-229-12
- Cetirizine Hydrochloride 10 mg Tablet, Orally Disintegrating NDC 69842-234-76
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- Cetirizine Hydrochloride (Allergy) 10 mg Tablet NDC 69842-237-01
- CVS Mineral Oil 1000 mg/mL Liquid NDC 69842-238-16
- Loratadine 10 mg Tablet NDC 69842-242-09
- CVS Cold and Hot Menthol 50 mg Patch NDC 69842-243-05
- CVS Cold and Hot Menthol 50 mg Patch NDC 69842-245-05
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.
- FDA openFDA NDC Directory · synced Oct 1, 2026
- Drugs@FDA
FDA label — Drug Facts FDA SPL
The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage
⏱️ Dosage and Administration
⚠️ Warnings
🧪 Active Ingredient
🧪 Inactive Ingredients
🎯 Purpose
📄 Do Not Use
📄 When Using This Product
📄 Stop Use and Ask a Doctor If
📄 Keep Out of Reach of Children
📄 Other Information
📄 Questions or Comments
📄 Package Label / Principal Display Panel
🎯 Indications and Usage ▾
Uses for the temporary relief of pain and itching associated with: minor burns sunburn minor cuts scrapes insect bites minor skin irritations rashes due to poison ivy, poison oak and poison sumac dries the oozing and weeping of poison ivy, poison oak and poison sumac
⏱️ Dosage and Administration ▾
Directions do not use more often than directed adults and children 2 years of age and older: apply to affected area not more than 3 to 4 times daily children under 2 years of age: ask a doctor
⚠️ Warnings ▾
Warnings For external use only. Flammable: Keep away from fire or flame. Do not puncture or incinerate.
Contents under pressure. Do not store at temperatures above 120°F. Intentional misuse by delibrately concenrating and inhaling contents can be harmful or fatal. Do not use on large areas of the body with any other product containing diphenhydramine, even one taken by mouth Ask a doctor before use on chicken pox on measles When using this product avoid contact with eyes Stop use and ask doctor if conditions worsens symptoms last more than 7 days or clear up and occur again within a few days Keep out of reach of children.
If swallowed, get medical help or contact a Poison Control Center right away.
Ask a doctor before use on chicken pox on measles
🧪 Active Ingredient ▾
Active ingredients Diphenhydramine HCl 2.0%, Zinc Acetate 0.1%
🧪 Inactive Ingredients ▾
Inactive ingredients aloe barbadensis leaf juice, glycerin, purified water, SD alcohol 40-B, tromethamine
🎯 Purpose ▾
Purpose External analgesic Skin protectant
📄 Do Not Use ▾
Do not use on large areas of the body with any other product containing diphenhydramine, even one taken by mouth
📄 When Using This Product ▾
When using this product avoid contact with eyes
📄 Stop Use and Ask a Doctor If ▾
Stop use and ask doctor if conditions worsens symptoms last more than 7 days or clear up and occur again within a few days
📄 Keep Out of Reach of Children ▾
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
📄 Other Information ▾
Other information store between 20° to 25°C (68° to 77°F)
📄 Questions or Comments ▾
Questions? 1-866-964-0939
📄 Package Label / Principal Display Panel ▾
Principal Display Panel CVS Extra Strength ITCH RELIEF SPRAY Diphenhydramine HCl 2% Topical Analgesic Zinc Acetate 0.1% Skin Protectant Compare to Benadryl® Extra Strength Itch Cooling Spray active ingredients* Relieves Itching From : Insect bites, Poison ivy, oak & sumac Soothes Sunburn, Minor Burns & Cuts Sprays at Any Angle For Topical Use Only NET WT
2.7 OZ (76g) carton
No label section mentions that — try another word, or open the full label on DailyMed below.
Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA.
Prefer the government’s original formatting? View this label on DailyMed ↗
About this NDC listing & data coverage
Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | ✓ Available |
| Inactive ingredients (structured) | ✓ Available |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope. |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.
Questions about this listing
Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by CVS Pharmacy. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
CVS Pharmacy is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
For educational and professional reference only — not medical advice. Pricing reflects published
NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.