Home › NDC Lookup › Ingredients › Diphenhydramine Hcl, Zinc Acetate › 69842-0952-02
CVS Itch Relief Diphenhydramine HCl, Zinc Acetate .1 g/100mL; 2 g/100mL Spray, 59 mL — NDC 69842-0952-02 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

CVS Itch Relief Diphenhydramine HCl, Zinc Acetate .1 g/100mL; 2 g/100mL Spray, 59 mL — NDC 69842-952-02 (Billing 69842-0952-02)

by CVS · 59 mL in 1 BOTTLE, SPRAY

This is a package of 59 mL of CVS Itch Relief Diphenhydramine HCl, Zinc Acetate .1 g/100mL; 2 g/100mL Spray from CVS, marketed since Apr 2014 and currently FDA-listed. It is this product's only package size.

NDC 69842-0952-02
🏷️ FDA NDC (as labeled) 69842-952-02 billing pads the product segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 8, 2026 · this listing last changed Aug 27, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 69842-952-02 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
69842 labeler · 952 product · 02 package
Package marketed since
Apr 14, 2014
Sample package
No — commercial package
Listing certified through
Dec 31, 2026
Billing quantity
59 mL per package
Barcode (UPC)
0050428431566
FDA record last changed
Aug 27, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 69842-952-02
Product NDC 69842-952
11-digit billing NDC 69842095202
NCPDP billing unit ML — per mL (volume)
RxCUI 1053138
UNII FM5526K07A, TC2D6JAD40
UPC 0050428431566
Application # M017
SPL Set ID 8723e097-296f-784a-e053-2991aa0a552e
Established class (EPC) Copper Absorption Inhibitor; Histamine-1 Receptor Antagonist
Mechanism of action Histamine H1 Receptor Antagonists
Physiologic effect Decreased Copper Ion Absorption
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2014-04-14
Route TOPICAL
Dosage form SPRAY
Substance ZINC ACETATE; DIPHENHYDRAMINE HYDROCHLORIDE
Quick answers
  • RxCUI (RxNorm): 1053138
Why two NDCs? The FDA registers this code as 69842-952-02 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 69842-0952-02. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Histamine-1 Receptor Antagonist class.

Pharmacologic class Histamine-1 Receptor Antagonist
Drug family (ATC) Propionic acid derivatives, Antihistamines for topical use, Aminoalkyl ethers
How it works Histamine H1 Receptor Antagonists
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

🧪 What is this product?

CVS Itch Relief is an over-the-counter topical spray marketed under the FDA's OTC monograph rules for skin-itch products. It contains diphenhydramine hydrochloride, a first-generation antihistamine commonly used to reduce itching and skin irritation when applied directly to the skin, and zinc acetate, which is typically included in itch-relief formulations for its astringent and soothing properties. The spray form allows direct application to affected areas.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
69842-0952-02 You're viewing this Main listing 59 mL in 1 BOTTLE, SPRAY 2014-04-14 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Good neighbor Pharmacy Itch Relief .1 g/100mL; 2 g/100mL 46122-0572-46 AMERISOURCEBERGEN 59 ml $0.047 — Availability likely —
Itch Relief 20 mg/mL; 1 mg/mL 70000-0023-01 Cardinal 59 ml $0.047 — Availability likely —
Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 00363-0215-76 Walgreen 76 g — — FDA listed —
Extra Strength Wal-Dryl Itch Relief 20 mg/mL; 1 mg/mL 00363-2177-00 WALGREEN 88 ml — — FDA listed —
Rite Aid Itch Relief 2 g/100g; .1 g/100g 11822-0647-02 Rite 59 g — — FDA listed —
Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 30142-0134-27 Kroger 76 g — — Discontinued —
Diphenhydramine HCl and Zinc Acetate 1.5 g/76g; .075 g/76g 36800-0126-76 Topco 76 g — — FDA listed —
Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 37808-0526-27 HEB 76 g — — FDA listed —
Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 41250-0058-30 Meijer 76 g — — FDA listed —
Itch Relief 20 mg/mL; 1 mg/mL 41250-0295-20 Meijer, 59 ml — — FDA listed —
Itch Relief 1 mg/g; 20 mg/g 42507-0986-76 HY-VEE, 76 g — — FDA listed —
Diphenhydramine HCl and Zinc Acetate 1.5 g/88mL; .075 g/88mL 49035-0015-03 Wal-Mart 88 ml — — FDA listed —
GoodSense Anti-Itch 2 g/100mL; .1 g/100mL 50804-0064-02 Geiss, 59 ml — — FDA listed —
Itch Relief 20 mg/mL; 1 mg/mL 55910-0295-20 Old 59 ml — — FDA listed —
Itch Relief 1 mg/mL; 20 mg/mL 59450-0295-20 The 59 ml — — FDA listed —
Quality Choice Itch Relief .1 g/100mL; 2 g/100mL 63868-0952-02 Chain 59 ml — — FDA listed —
Best Choice Itch Relief .1 g/100mL; 2 g/100mL 63941-0259-02 Valu 59 ml — — FDA listed —
Itch Relief 1.5 g/76g; .076 g/76g 69842-0235-27 CVS 76 g — — FDA listed —
CVS Itch Relief .1 g/100mL; 2 g/100mLthis 69842-0952-02 CVS 59 ml — — FDA listed —
Benadryl Extra Strength Itch Cooling 20 mg/mL; 1 mg/mL 69968-0270-02 Kenvue 59 ml — — FDA listed —
Itch Relief 20 mg/mL; 1 mg/mL 72476-0295-20 Retail 059 l — — Discontinued —
Warrior First Aid Anti Itch 2 g/100mL; .1 g/100mL 72839-0647-02 Derma 59 ml — — FDA listed —
Extra Strength Itch Relief 20 mg/g; 1 mg/g 79481-0598-01 Meijer 76 g — — FDA listed —
Westlake Itch Relief .1 g/100mL; 2 g/100mL 82895-0715-60 Westlake 59 ml — — FDA listed —
Extra Strength Itch Relief 20 mg/g; 1 mg/g 83324-0302-27 Chain 76 g — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2014
On the market since
Apr 2014
📍
2026
Currently FDA-listed
12 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 3K9958V90M
    A liquid solvent derived from fermentation or chemical synthesis. In medicines, alcohol dissolves active ingredients, helps preserve the product, and improves how the body absorbs certain drugs.
  • UNII PDC6A3C0OX
    Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
  • UNII U725QWY32X
    Povidone K30 is a synthetic polymer made from petroleum. It acts as a binder to hold tablet ingredients together and as a disintegrant to help the tablet break apart in the stomach so the medicine can be absorbed.
  • UNII 9O3K93S3TK
    Trolamine is an alkaline compound used as a pH buffer and emulsifier in medicines. It helps neutralize acids, stabilize formulations, and enable mixing of oil and water-based ingredients.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

5 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesPurified Water, Glycerin, SD Alcohol, Povidone, Povidonee (K-30), Trolamine

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerCVS
FDA applicationM017 (OTC MONOGRAPH DRUG)
Labeler code69842
First marketedApr 2014
Product typeHuman Otc Drug
Portfolio100 products on file

More NDCs from CVS labeler code 69842

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings and Cautions ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Do Not Use 📄 Ask a Doctor Before Use If 📄 When Using This Product 📄 Stop Use and Ask a Doctor If 📄 Keep Out of Reach of Children 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 39 words ▾

for temporary relieves pain and itching due to: insect bites minor burns sunburn minor skin irritations minor cuts scrapes rashes due to poison ivy, poison oak, and poison sumac dries the oozing and weeping of poison: ivy oak sumac

⏱️ Dosage and Administration 33 words ▾

do not use more often than directed adults and children 2 years and older: apply to affected area not more than 3 to 4 times daily children under 2 years: ask a doctor

⚠️ Warnings and Cautions 89 words ▾

For external use only Do not Use on large areas of the body with any other product containing diphenhydramine, even one taken by mouth Ask doctor Before use on chicken pox on measles When using this product do not get into eyes Stop Use and ask physician condition worsens symptoms last more than 7 days or clear up and occur again within a few days Keep out of reach of children If swallowed, get medical help or contact a Poison Control Center right away. Warning for external use only

⚠️ Warnings 5 words ▾

Warning for external use only

🧪 Active Ingredient 10 words ▾

Diphenhydramine hydrochloride 2% Topical analgesic Zinc acetate 0.1% Skin protectant

🧪 Inactive Ingredients 9 words ▾

Purified Water, Glycerin, SD Alcohol, Povidone, Povidonee (K-30), Trolamine

🎯 Purpose 10 words ▾

Diphenhydramine hydrochloride 2% Topical analgesic Zinc acetate 0.1% Skin protectant

📄 Do Not Use 20 words ▾

Do not Use on large areas of the body with any other product containing diphenhydramine, even one taken by mouth

📄 Ask a Doctor Before Use If 9 words ▾

Ask doctor Before use on chicken pox on measles

📄 When Using This Product 9 words ▾

When using this product do not get into eyes

📄 Stop Use and Ask a Doctor If 23 words ▾

Stop Use and ask physician condition worsens symptoms last more than 7 days or clear up and occur again within a few days

📄 Keep Out of Reach of Children 19 words ▾

Keep out of reach of children If swallowed, get medical help or contact a Poison Control Center right away.

📄 Package Label / Principal Display Panel 32 words ▾

Diphenhydramine hydrochloride 2% Topical analgesic Zinc acetate 0.1% Skin protectant Relieves Itch and Pain associated with insects bites & rashes due to posinon ivy Oak& sumac CVS itch spray .jpg Back Label

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by CVS. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
CVS is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 69842-0950-01 · CVS 69842-0953-20 · CVS →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.