Leader Ibuprofen PM diphenhydramine citrate, 38 mg; 200 mg Tablet, Film Coated, 40-count
🆔 Identity & classification
Where does this data come from?
🏷️ RxNorm drug class
This medicine belongs to the Histamine-1 Receptor Antagonist class.
Where does this data come from?
🏭 Manufacturer & labeler
Where does this data come from?
🩺 Clinical
Diphenhydramine is used to treat allergy and cold symptoms: sneezing runny nose red, itchy, watery eyes itching of the nose or throat Diphenhydramine is also used to treat insomnia (difficulty falling asleep or staying asleep) in adults, but should not be used to make a child sleepy. Diphenhydramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Diphenhydramine is also available in combination with other medications. This monograph only includes information about the use of diphenh...
Read the full MedlinePlus article ↗- No — this product is specifically for nights when you have both minor pain AND trouble sleeping at the same time. It's not meant to be used as a plain sleep aid. If you're struggli...
- What exactly is this medicine for — can I just take it to help me sleep?
- Take 2 capsules or caplets at bedtime — whichever form your product comes in. Don't take more than that in 24 hours. If it bothers your stomach, go ahead and take it with food or a...
- How do I take it, and is it okay to take with food?
Patient education
Supplement & herbal interactions
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Ask a licensed pharmacist directly — free, answered by our team.
💊 What it looks like
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🧪 Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
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UNII M28OL1HH48
Croscarmellose sodium is a plant-based substance derived from cellulose. It acts as a disintegrant, helping tablets and capsules break down quickly in the digestive system so the medicine can be absorbed.
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UNII L06K8R7DQK
A synthetic blue dye approved by the FDA for use in medications and foods. It serves as a colorant to make pills and liquids visually distinct and easier to identify.
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UNII XM0M87F357
A dark iron oxide compound that gives medicines their black or dark color. It's used as a colorant in tablets and capsules to help identify the product and make it visually distinctive.
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UNII R8WTH25YS2
Glyceryl dibehenate is a wax-like substance made from behenate fatty acids and glycerol. It functions as a binder and release-control agent in tablets and capsules, helping hold ingredients together and regulate how quickly the medicine dissolves and releases in your body.
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UNII 9XZ8H6N6OH
A plant-based cellulose derivative used as a binder to hold tablet ingredients together, a thickener in liquids, and a coating agent to control how fast the medicine dissolves.
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UNII EWQ57Q8I5X
Lactose monohydrate is a natural sugar derived from milk. It serves as a filler and binder in tablets and capsules, helping create the proper size, texture, and consistency of the medicine.
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UNII 70097M6I30
Magnesium stearate is a salt made from magnesium and stearic acid, a fatty substance. It's used in tablets and capsules as a lubricant and glidant to help ingredients flow smoothly during manufacturing and prevent sticking.
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UNII OP1R32D61U
Microcrystalline cellulose is a purified form of cellulose, a natural fiber from plant sources. It acts as a binder and filler in tablets and capsules, helping hold ingredients together and give the medicine its shape and size.
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UNII 3WJQ0SDW1A
Polyethylene glycol is a synthetic liquid or solid polymer used in medicines as a solvent, lubricant, and humectant. It helps dissolve active ingredients, reduces friction during manufacturing, and retains moisture in the final product.
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UNII 532B59J990
Polyvinyl alcohol is a synthetic polymer made from plant-derived materials. It's used as a binder to hold ingredients together, a film-former in coatings, and a thickener in liquid formulations.
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UNII ETJ7Z6XBU4
Silicon dioxide is a naturally occurring mineral used as a glidant and anti-caking agent. It helps powder ingredients flow smoothly and prevents clumping during manufacturing and storage.
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UNII 7SEV7J4R1U
A powder made from a naturally occurring mineral. In medicines, talc works as a glidant and anti-caking agent, helping tablets and capsules flow smoothly during manufacturing and preventing clumping.
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UNII 15FIX9V2JP
Titanium dioxide is a bright white mineral powder commonly used as a colorant and opacifying agent. It makes pills and tablets white or lighter in color and helps make coatings non-transparent.
13 inactive ingredients listed in the exact product block matched to this NDC.
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
Why might an inactive ingredient be missing?
Can inactive ingredients matter?
💲 Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per ea | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | $0.125 | $5.00 / 40 tablets |
| Medicaid paysCMS SDUD · 12 mo | $0.3194 | $12.78 / 40 tablets |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
Where does this data come from?
🔁 Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| good neighbor pharmacy ibuprofen pm 38 mg/1; 200 mg 46122-0708-41 | Amerisource | 80 tablets | $0.122 | — | Discontinued | save 2% |
| Leader Ibuprofen PM 38 mg/1; 200 mgthis 70000-0157-01 | Cardinal | 40 tablets | $0.125 | — | FDA listed | — |
| good sense ibuprofen pm 38 mg/1; 200 mg 00113-0050-58 | L. | 40 tablets | $0.131 | — | Availability likely | +5% |
| foster and thrive ibuprofen pm 38 mg/1; 200 mg 70677-1131-01 | Strategic | 40 tablets | $0.131 | — | Availability likely | +5% |
| Ibuprofen PM 38 mg/1; 200 mg 00363-0050-27 | Walgreen | 80 tablets | — | — | FDA listed | — |
| Advil Pm 38 mg/1; 200 mg 00573-0164-04 | Haleon | 4 tablets | — | — | FDA listed | — |
| up and up ibuprofen pm 38 mg/1; 200 mg 11673-0050-58 | Target | 40 tablets | — | — | FDA listed | — |
| ibuprofen pm 38 mg/1; 200 mg 11822-0050-01 | Rite | 80 tablets | — | — | Discontinued | — |
| Ibuprofen PM 200 mg/1; 38 mg 21130-0056-40 | Safeway, | 40 tablets | — | — | FDA listed | — |
| Ibuprofen and Diphenhydramine Citrate 200 mg/1; 38 mg 21130-0228-12 | Better | 40 tablets | — | — | FDA listed | — |
| Signature Care Ibuprofen PM 38 mg/1; 200 mg 21130-0283-27 | Safeway | 80 tablets | — | — | Discontinued | — |
| Ibuprofen Pm 38 mg/1; 200 mg 21130-0623-76 | Safeway | 120 tablets | — | — | FDA listed | — |
| ADVIL PM- diphenhydramine citrate and ibuprofen tablet, coated 38 mg/1; 200 mg 29485-6533-04 | Lil | 2 tablets | — | — | FDA listed | — |
| ADVIL PM- diphenhydramine citrate and ibuprofen tablet, coated 38 mg/1; 200 mg 29485-7008-03 | Lil | 2 tablets | — | — | FDA listed | — |
| ibuprofen pm 38 mg/1; 200 mg 30142-0050-27 | Kroger | 80 tablets | — | — | FDA listed | — |
| Ibuprofen PM 200 mg/1; 38 mg 30142-0278-80 | KROGER | 80 tablets | — | — | FDA listed | — |
| Topcare Ibuprofen PM 38 mg/1; 200 mg 36800-0050-27 | Topco | 80 tablets | — | — | FDA listed | — |
| ibuprofen pm 38 mg/1; 200 mg 37808-0703-60 | H | 20 tablets | — | — | FDA listed | — |
| equaline ibuprofen pm 38 mg/1; 200 mg 41163-0050-27 | United | 80 tablets | — | — | FDA listed | — |
| Ibuprofen PM 38 mg/1; 200 mg 41250-0050-27 | Meijer | 80 tablets | — | — | Discontinued | — |
| Care One Ibuprofen PM 38 mg/1; 200 mg 41520-0050-27 | American | 80 tablets | — | — | FDA listed | — |
| ibuprofen pm 38 mg/1; 200 mg 42507-0050-27 | HyVee | 80 tablets | — | — | FDA listed | — |
| equate ibuprofen pm 38 mg/1; 200 mg 49035-0699-27 | Wal-Mart | 80 tablets | — | — | FDA listed | — |
| Motrin PM 200 mg/1; 38 mg 50580-0563-20 | Kenvue | 20 tablets | — | — | FDA listed | — |
| Ibuprofen and Diphenhydramine Citrate 200 mg/1; 38 mg 55111-0565-05 | Dr. | 500 tablets | — | — | FDA listed | — |
| Exchange Select Ibuprofen PM 38 mg/1; 200 mg 55301-0050-60 | Army | 20 tablets | — | — | FDA listed | — |
| Ibuprofen PM 200 mg/1; 38 mg 55319-0197-20 | Family | 20 tablets | — | — | FDA listed | — |
| dg health Ibuprofen pm 38 mg/1; 200 mg 55910-0050-27 | Dolgencorp | 80 tablets | — | — | FDA listed | — |
| Ibuprofen and Diphenhydramine Citrate 200 mg/1; 38 mg 58602-0867-09 | Aurohealth | 30 tablets | — | — | FDA listed | — |
| ibuprofen pm 38 mg/1; 200 mg 59779-0050-27 | CVS | 80 tablets | — | — | FDA listed | — |
| Ibuprofen 200 mg and Diphenhydramine Citrate 38 mg 200 mg/1; 38 mg 63548-0197-02 | PLD | 20 tablets | — | — | FDA listed | — |
| Advil PM, TRAVEL BASIX 200 mg/1; 38 mg 66715-6433-02 | Lil' | 2 tablets | — | — | FDA listed | — |
| Advil PM, CVP HEALTH 200 mg/1; 38 mg 66715-6533-02 | Lil' | 2 tablets | — | — | FDA listed | — |
| Advil PM 200 mg/1; 38 mg 66715-9633-03 | Lil' | 2 tablets | — | — | FDA listed | — |
| Advil PM 200 mg/1; 38 mg 66715-9733-02 | Lil' | 2 tablets | — | — | FDA listed | — |
| Advil PM 38 mg/1; 200 mg 67751-0147-01 | Navajo | 2 tablets | — | — | FDA listed | — |
| Ibuprofen PM 200 mg/1; 38 mg 69607-1970-01 | WR | 120 tablets | — | — | FDA listed | — |
| basic care ibuprofen pm 38 mg/1; 200 mg 72288-0050-60 | Amazon.com | 20 tablets | — | — | FDA listed | — |
| Amazon Basic Care Ibuprofen Pm 200 mg/1; 38 mg 72288-0061-77 | Amazon.com | 120 tablets | — | — | FDA listed | — |
| Ibuprofen PM 200 mg/1; 38 mg 79903-0186-20 | WALMART | 20 tablets | — | — | FDA listed | — |
| ibuprofen pm 38 mg/1; 200 mg 56062-0050-58 | Publix | 40 tablets | — | — | FDA listed | — |
Where does this data come from?
⏳ Availability & generic status
This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.
Where does this data come from?
🗺️ Medicaid utilization & spend
💊 Medicaid utilization by pack size
🔬 Reported adverse events (FAERS)
Top reported reactions
Age at onset
Reporter sex
Where does this data come from?
📦 Packaging — all sizes for this product
| Package NDC | Description | Per unit | Per pack | Marketing start | Status |
|---|---|---|---|---|---|
| 70000-0157-01 You're viewing this | 1 BOTTLE in 1 CARTON (70000-0157-1) / 40 TABLET, FILM COATED in 1 BOTTLE | $0.1250 / ea | $5.00 | 2016-11-23 | Active |
| 70000-0157-02 | 1 BOTTLE in 1 CARTON (70000-0157-2) / 80 TABLET, FILM COATED in 1 BOTTLE | — | — | 2016-11-23 | Discontinued by firm |
| 70000-0157-03 | 1 BOTTLE in 1 CARTON (70000-0157-3) / 20 TABLET, FILM COATED in 1 BOTTLE | $0.1307 / ea | $2.61 | 2024-11-21 | Active |
This pack has the lowest per-ea cost of the 2 priced pack sizes ($0.1250 NADAC).
Pack size FAQ
What quantity is in NDC 70000-0157-01?
What is the difference between NDC 70000-0157-01 and NDC 70000-0157-03?
What NDC number is used to bill for this package of Leader Ibuprofen PM diphenhydramine citrate, 38 mg; 200 mg Tablet, Film Coated?
Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.
📄 FDA label — Drug Facts FDA SPL
🎯 Indications and Usage ▾
Uses • for relief of occasional sleeplessness when associated with minor aches and pains • helps you fall asleep and stay asleep
⏱️ Dosage and Administration ▾
Directions • do not take more than directed • adults and children 12 years and over: take 2 caplets at bedtime • do not take more than 2 caplets in 24 hours
⚠️ Warnings ▾
Warnings Allergy alert: Ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include: • hives • facial swelling • asthma (wheezing) • shock • skin reddening • rash • blisters If an allergic reaction occurs, stop use and seek medical help right away. Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding.
The chance is higher if you • are age 60 or older • have had stomach ulcers or bleeding problems • take a blood thinning (anticoagulant) or steroid drug • take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others] • have 3 or more alcoholic drinks every day while using this product • take more or for a longer time than directed Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed.
Do not use • if you have ever had an allergic reaction to any other pain reliever/fever reducer • unless you have time for a full night’s sleep • in children under 12 years of age • right before or after heart surgery • with any other product containing diphenhydramine, even one used on skin • if you have sleeplessness without pain Ask a doctor before use if • stomach bleeding warning applies to you • you have problems or serious side effects from taking pain relievers or fever reducers • you have a history of stomach problems, such as heartburn • you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke • you are taking a diuretic • you have a breathing problem such as emphysema or chronic bronchitis • you have glaucoma • you have trouble urinating due to an enlarged prostate gland Ask a doctor or pharmacist before use if you are • taking sedatives or tranquilizers, or any other sleep-aid • under a doctor’s care for any continuing medical illness • taking any other antihistamines • taking aspirin for heart attack or stroke, because ibuprofen may decrease this benefit of aspirin • taking any other drug When using this product • drowsiness will occur • avoid alcoholic drinks • do not drive a motor vehicle or operate machinery • take with food or milk if stomach upset occurs Stop use and ask a doctor if • you experience any of the following signs of stomach bleeding: • feel faint • vomit blood • have bloody or black stools • have stomach pain that does not get better • you have symptoms of heart problems or stroke: • chest pain • trouble breathing • weakness in one part or side of body • slurred speech • leg swelling • pain gets worse or lasts more than 10 days • sleeplessness persists continuously for more than 2 weeks.
Insomnia may be a symptom of a serious underlying medical illness. • redness or swelling is present in the painful area • any new symptoms appear If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use ibuprofen at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Keep out of reach of children.
In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222).
📦 Storage and Handling ▾
Other information • read all warnings and directions before use. Keep carton. • store at 20-25°C (68-77°F) • avoid excessive heat above 40°C (104°F)
🧪 Active Ingredient ▾
Active ingredients (in each caplet) Diphenhydramine citrate 38 mg Ibuprofen 200 mg (NSAID)* *nonsteroidal anti-inflammatory drug
🧪 Inactive Ingredients ▾
Inactive ingredients colloidal silicon dioxide, croscarmellose sodium, FD&C blue no. 2 aluminum lake, glyceryl behenate, hydroxypropyl cellulose, iron oxide black, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, pregelatinized starch, talc, titanium dioxide
🎯 Purpose ▾
Purposes Nighttime sleep-aid Pain reliever