Tussin Expectorant GUAIFENESIN 100 mg/5mL Liquid, 118 mL
by AptaPharma, Inc. · 118 mL in 1 BOTTLE (76281-507-24)
NDC 76281-0507-24
🏷️ FDA NDC (as labeled)
76281-507-24
billing pads the product segment with a zero
OTC
On market
Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →
🆔 Identity & classification
FDA NDC (as labeled)
76281-507-24
Product NDC
76281-507
11-digit billing NDC
76281050724
RxCUI
310604
UNII
495W7451VQ
Application #
M012
SPL Set ID
ca8fa216-09c1-42b2-a95b-fa3d0f13363c
Established class (EPC)
Expectorant
Physiologic effect
Decreased Respiratory Secretion Viscosity; Increased Respiratory Secretions
DEA schedule
Non-controlled
Marketing category
OTC MONOGRAPH DRUG
Marketing status
On market
FDA listing status
Listed (active directory)
Marketing start
2020-09-30
Route
ORAL
Dosage form
LIQUID
Substance
GUAIFENESIN
Why two NDCs?
The FDA registers this code as 76281-507-24 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 76281-0507-24. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.
🏷️ RxNorm drug class
This medicine belongs to the Expectorant class.
Pharmacologic class
Expectorant
Drug family (ATC)
Expectorants
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.
🏭 Manufacturer & labeler
LabelerAptaPharma, Inc.
FDA applicationM012 (OTC MONOGRAPH DRUG)
Labeler code76281
First marketedSep 2020
Product typeHuman Otc Drug
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.
🩺 Clinical
📖 What it is MedlinePlus · NLM
Guaifenesin is used to relieve chest congestion. Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery. Guaifenesin is in a class of medications called expectorants. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways.
Read the full MedlinePlus article ↗📗 Our plain-language guide HelloPharmacist
- Guaifenesin is what's called an expectorant — it works to thin and loosen the mucus sitting in your chest and airways. That makes it easier to cough the mucus up and out, so instea...
- What exactly does guaifenesin do for my cough?
- Guaifenesin is meant for short-term use. If your cough isn't getting better after 7 days, keeps coming back, or shows up alongside a fever, rash, or a headache that won't go away,...
- How long can I take it before I should call my doctor?
Patient education
Supplement & herbal interactions
Some supplements/herbs that may interact with Guaifenesin — tap one for details:
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.
💬 Questions about GUAIFENESIN?
Ask a pharmacist →
Ask a licensed pharmacist directly — free, answered by our team.
💊 What it looks like
Color
red
FlavorCherry
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.
🧪 Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
-
UNII XF417D3PSL
Anhydrous citric acid is a sour, crystalline powder derived from citric acid with water removed. In medicines, it acts as a buffer to control pH, adds tartness to improve taste, and helps tablets disintegrate.
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UNII T9D99G2B1R
Caramel is a brown coloring substance made by heating sugar. It's added to medicines to give them color and sometimes a slight sweet taste without affecting how the drug works.
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UNII IY9XDZ35W2
Dextrose is a simple sugar derived from corn or other sources. It serves as a filler and sweetener in medicines to add bulk, improve taste, and help stabilize the medication's form.
-
UNII WZB9127XOA
A synthetic red dye used to color medications and make them easier to identify. It serves as a colorant in tablets, capsules, and liquid formulations.
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UNII PDC6A3C0OX
Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
-
UNII XY6UN3QB6S
A sweetener made from corn starch that contains fructose and glucose. It sweetens the medicine to improve taste and may help preserve the product.
-
UNII L7T10EIP3A
A cooling compound from mint plants used as a flavoring agent and to create a fresh sensation in medicines. It helps mask bitter tastes and improve how the product feels in the mouth.
-
UNII SB8ZUX40TY
Saccharin sodium is an artificial sweetener made from saccharin salt. It's added to medicines to improve taste, especially in liquid formulations for children or bitter drugs.
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UNII OJ245FE5EU
Sodium benzoate is a salt derived from benzoic acid, a preservative. It's added to medicines to prevent growth of bacteria, fungi, and other microorganisms that could spoil the product.
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UNII 059QF0KO0R
Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
10 inactive ingredients listed in the exact product block matched to this NDC.
The official label also statesInactive ingredients Caramel, citric acid anhydrous, dextrose, FD&C red #40, flavor, glycerin, high fructose corn syrup, menthol, purified water, saccharin sodium, sodium benzoate
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed —
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.
💲 Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per mL | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.
🔁 Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Chest Congestion Relief 100 mg/5mL 00536-1314-85 | RUGBY | 473 ml | $0.011 | — | Availability likely | — |
| Guaifenesin 100 mg/5mL 58657-0508-16 | Method | 473 ml | $0.011 | — | Availability likely | — |
| Guaifenesin 100 mg/5mL 83720-0503-16 | Oncor | 473 ml | $0.011 | — | Availability likely | — |
| Guaifenesin 100 mg/5mL 58657-0509-16 | Method | 473 ml | $0.013 | — | FDA listed | — |
| Good Neighbor Adult Tussin Mucus and chest congestion 200 mg/10mL 46122-0785-29 | AMERISOURCE | 1 bottle | $0.023 | — | Availability likely | — |
| Tusnel EX 100 mg/5mL 54859-0507-04 | Llorens | 118 ml | $0.023 | — | Availability likely | — |
| Mucolyte 100 mg/5mL 57237-0359-12 | Rising | 118 ml | $0.023 | — | Availability likely | — |
| Tussin 200 mg/10mL 70677-1186-01 | Strategic | 1 bottle | $0.023 | — | Availability likely | — |
| Tussin Mucus and Chest Congestion Sugar Free 200 mg/10mL 82568-0012-04 | AARNA | 1 bottle | $0.023 | — | Availability likely | — |
| QCH Adult Tussin 541 200 mg/10mL 83324-0024-04 | Chain | 1 bottle | $0.023 | — | Availability likely | — |
| Mucinex Fast-Max Chest Congestion Honey and Berry Flavor 400 mg/20mL 63824-0537-66 | Reckitt | 180 ml | $0.061 | — | FDA listed | — |
| Guaifenesin 100 mg/5mL 00121-0744-04 | PAI | 118 ml | — | — | FDA listed | — |
| Guaifenesin 200 mg/10mL 00121-1488-00 | PAI | 10 cups | — | — | FDA listed | — |
| Guaifenesin 100 mg/5mL 00121-1744-00 | PAI | 10 cups | — | — | FDA listed | — |
| Guaifenesin 300 mg/15mL 00121-2232-00 | PAI | 10 cups | — | — | FDA listed | — |
| Walgreen Cherry 200 mg/10mL 00363-7043-08 | WALGREEN | 1 bottle | — | — | FDA listed | — |
| Childrens Chest Congestion Relief 100 mg/5mL 00363-7504-04 | WALGREENS | 1 bottle | — | — | FDA listed | — |
| Tusnel EX 100 mg/5mL 50090-6542-00 | A-S | 118 ml | — | — | FDA listed | — |
| CVS Adult Mucus plus Chest Congestion 200 mg/10mL 51316-0437-08 | CVS | 1 bottle | — | — | FDA listed | — |
| CVS Adult Mucus chest congestion 200 mg/10mL 51316-0743-08 | CVS | 1 bottle | — | — | FDA listed | — |
| Tussin 100 mg/5mL 53943-0507-26 | Discount | 237 ml | — | — | FDA listed | — |
| Childrens Chest Congestion Relief Grape 100 mg/5mL 53943-0511-24 | Discount | 118 ml | — | — | FDA listed | — |
| Llorens Care Tussin 100 mg/5mL 54859-0510-16 | Llorens | 473 ml | — | — | FDA listed | — |
| Guaifenesin 200 mg/10mL 55154-5780-05 | Cardinal | 5 cups | — | — | FDA listed | — |
| Guaifenesin 100 mg/5mL 55154-9450-05 | Cardinal | 5 cups | — | — | FDA listed | — |
| Geri-Tussin 200 mg/10mL 57896-0293-16 | Geri-Care | 473 ml | — | — | FDA listed | — |
| Geri-Tussin 100 mg/5mL 57896-0693-16 | Geri-Care | 473 ml | — | — | FDA listed | — |
| Cough Out 100 mg/5mL 58593-0255-04 | Efficient | 118 ml | — | — | Discontinued | — |
| Rompe Pecho SF 100 mg/5mL 58593-0265-04 | Efficient | 118 ml | — | — | Discontinued | — |
| Rompe Pecho EX 200 mg/10mL 58593-0829-04 | Efficient | 118 ml | — | — | FDA listed | — |
| Guaifenesin 100 mg/5mL 60687-0852-17 | American | 10 cups | — | — | FDA listed | — |
| Guaifenesin 200 mg/10mL 60687-0863-56 | American | 10 cups | — | — | FDA listed | — |
| Guaifenesin 300 mg/15mL 60687-0874-16 | American | 10 cups | — | — | FDA listed | — |
| Childrens Mucus Relief Chest Congestion 100 mg/5mL 63868-0770-04 | Chain | 1 bottle | — | — | FDA listed | — |
| SDA Laboratories Tussin 100 mg/5mL 66424-0563-16 | SDA | 473 ml | — | — | FDA listed | — |
| DRx Choice Fruit Punch 200 mg/10mL 68163-0743-04 | Raritan | 1 bottle | — | — | FDA listed | — |
| Adult Tussin 200 mg/10mL 69230-0332-23 | Camber | 1 bottle | — | — | FDA listed | — |
| Reliable-1 Tussin 100 mg/5mL 69618-0068-54 | RELIABLE | 118 ml | — | — | FDA listed | — |
| Akin 100 mg/5mL 69822-0200-02 | Southern | 118 ml | — | — | FDA listed | — |
| MAX Tussin Mucus and Chest Congestion Sugar Free 200 mg/10mL 71399-0024-04 | Akron | 1 bottle | — | — | FDA listed | — |
| MAX Tussin Mucus and Chest Congestion 200 mg/10mL 71399-0054-08 | Akron | 1 bottle | — | — | FDA listed | — |
| Guaifenesin STRAWBERRY-BANANA FLAVOR 100 mg/5mL 71800-0059-19 | Innovida | 119 ml | — | — | FDA listed | — |
| Guaifenesin 100 mg/5mL 72162-2278-02 | Bryant | 473 ml | — | — | FDA listed | — |
| Guaifed 200 mg/10mL 73564-0801-04 | Aldama | 118 ml | — | — | FDA listed | — |
| Tussin Expectorant 100 mg/5mLthis 76281-0507-24 | AptaPharma, | 118 ml | — | — | FDA listed | — |
| Meijer Adult Mucus Plus chest congestion 200 mg/10mL 79481-7430-08 | MEIJER | 1 bottle | — | — | FDA listed | — |
| Guaifenesin 100 mg/5mL 81033-0102-51 | KESIN | 50 cups | — | — | FDA listed | — |
| Quality Choice Adult Tussin Expectorant 200 mg/10mL 83324-0332-04 | QUALITY | 1 bottle | — | — | FDA listed | — |
| Curewell Tussin 100 mg/5mL 85111-0693-16 | RMT | 473 ml | — | — | FDA listed | — |
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.
⏳ Availability & generic status
🏛️
2020
On the market since
Sep 2020
📍
2026
Currently FDA-listed
6 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.
🔬 Reported adverse events (FAERS)
Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Tussin Expectorant (this brand).
Top reported reactions
Age at onset
Reporter sex
Male · 42%
Female · 57%
Unknown · 0%
Serious outcomes
Reports over time (by year) — tap or hover for the count & year
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.
📦 Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Status |
|---|---|---|---|
| 76281-0507-24 You're viewing this | 118 mL in 1 BOTTLE (76281-507-24) | 2020-09-30 | Active |
🧭 About this NDC listing & data coverage
Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | ✓ Available |
| Inactive ingredients (structured) | ✓ Available |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope. |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.
Questions about this listing
Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 76281-507-24, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 76281-0507-24, written without dashes as 76281050724. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 76281-0507-24, the first segment (76281) is the labeler code FDA assigned to AptaPharma, Inc.; the middle segment (0507) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (24) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by AptaPharma, Inc.. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
AptaPharma, Inc. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
📄 FDA label — Drug Facts FDA SPL
The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage
⏱️ Dosage and Administration
⚠️ Warnings
🧪 Active Ingredient
🧪 Inactive Ingredients
🎯 Purpose
🎯 Indications and Usage ▾
Uses ■ Helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive
⏱️ Dosage and Administration ▾
Directions ■ do not take more than 6 doses in any 24-hour period. Age Dose Adults and children 12 years and over 2-4 teaspoonfuls every 4 hours Children under 12 years do not use
⚠️ Warnings ▾
Warnings Ask a doctor before use if you have ■ cough that occurs with too much phlegm (mucus) ■ cough that lasts or is chronic such as occurs with smoking, asthma, chronic bronchitis, or emphysema
🧪 Active Ingredient ▾
Drug Facts Active ingredient (in each 5 mL teaspoon) Guaifenesin, USP ........ 100 mg
🧪 Inactive Ingredients ▾
Inactive ingredients Caramel, citric acid anhydrous, dextrose, FD&C red #40, flavor, glycerin, high fructose corn syrup, menthol, purified water, saccharin sodium, sodium benzoate
🎯 Purpose ▾
Purpose Expectorant
No label section mentions that — try another word, or open the full label on DailyMed below.
Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA.
Prefer the government’s original formatting? View this label on DailyMed ↗
For educational and professional reference only — not medical advice. Pricing reflects published
NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.