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J2281

J2281 – Injection, moxifloxacin (fresenius kabi) not therapeutically equivalent · NDC Crosswalk & Billing Units

HCPCS Level II J-code · Medicare Part B drug billing
J-code ● 1 NDC crosswalked per 100 MG $6.641/unit ASP+6%

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Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

📋 J2281 summary

J2281 is a HCPCS Level II J-code used to bill moxifloxacin (fresenius kabi) not therapeutically equivalent to j2280, 100 mg, billed per 100 MG. The number of billing units to report depends on the dose administered and the NDC/package billed — use the calculator below.

Code J2281 Billing unit 100 MG Payment limit $6.641/unit NDC-Crosswalk 1 Quarter Q3 2026 RxCUI Atlas Trace the drug concept →

⚠ An NDC↔HCPCS crosswalk and a published payment limit do not guarantee payer coverage or payment. Always verify the current payer policy and claim format before billing.

🗂️ Key billing facts

HCPCS codeJ2281
DescriptorInjection, moxifloxacin (fresenius kabi) not therapeutically equivalent to j2280, 100 mg
Billing unit100 MG
Payment limit / unit$6.641
Est. ASP / unit$6.265 est.
Mapped NDCs1
Data periodQ3 2026
Last updated2026-08-20

💊 About Moxifloxacin DRUG GUIDE

Moxifloxacin tablets and intravenous (IV) injection are approved for adults 18 and older to treat bacterial infections including community-acquired pneumonia, uncomplicated and complicated skin infections, complicated abdominal infections, plague, acute bacterial sinusitis, and acute bacterial flare-ups of chronic bronchitis.

Note: moxifloxacin should only be used for sinusitis and chronic bronchitis flare-ups when no other antibiotic option is available, due to the risk of serious side effects.Moxifloxacin ophthalmic solution (eye drops) — including the brand Vigamox — is a separate, topical formulation used only in the eye to treat bacterial conjunctivitis (pink eye) caused by susceptible bacteria.

The eye drop form is not used for body-wide infections.

Read the full Moxifloxacin drug guide →
Clinical overview from our editorial drug guide for Moxifloxacin. For billing reference, see the sections above.

🧾 Billing & reimbursement HCPCS · CMS · EFF. Q3 2026

📅 Payment limits effective Q3 2026 — from the CMS Medicare Part B Payment Limit File (revised quarterly).
Medicare payment limit / unit
$6.641
Est. ASP / unit
$6.265 est.
Est. after 2% sequester
$6.508
HCPCS dosage
100 MG
The CMS payment limit is the Medicare Part B drug allowance (ASP + 6%, statutory). After the 2% federal sequester the effective payment is ≈ ASP + 4.3%; estimated ASP = payment limit ÷ 1.06. Source: CMS Medicare Part B Payment Limit File (quarterly), Q3 2026.
Full HCPCS code details (official CMS record)
Long descriptionInjection, moxifloxacin (fresenius kabi) not therapeutically equivalent to j2280, 100 mg
CoverageC — Carrier/MAC judgment
Pricing indicator51 — Drug — priced under the ASP methodology
Type of service1 — Medical care
BETOS-2O1E
ASC payment groupYY
Action codeP — Payment change
Effective date2024-01-01
Date added2023-01-01
Source: CMS HCPCS Level II code file (imported via admin).

🧮 Dosing & billing-units calculator HCPCS UNITS

One billing unit of J2281 = 100 mg. Enter a regimen to convert dose → billing units and project a full course.
Billing units = dose ÷ HCPCS unit size. Most payers require whole units — round per the payer's policy. “Est. Medicare pay” uses the current payment limit. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (JZ when none is discarded) where allowed. Always verify payer-specific rounding before billing.

🔁 NDCs that bill under J2281 WITH EST. MEDICARE PAY

1 NDC map to J2281. Bill units = how many HCPCS units one package represents. Est. pay / pkg = payment limit ($6.641/unit) × that package's bill units.
NDC (11-digit)DrugLabelerPackageStrength Bill units Est. pay / pkg NADAC / unit StatusSource
63323-0850-74 Moxifloxacin HCl FreseniUS — — 48 $318.77 — — CMS + PDAC
NDC→HCPCS mappings come from the CMS ASP NDC-HCPCS crosswalk; additional DME MAC / DMEPOS mappings come from PDAC and are labeled separately. NADAC from CMS (weekly). “Status” reflects the product's marketing / obsolete flag in the NDC directory. Presence or absence here does not determine Medicare coverage. Linked NDCs open the full product page.

📈 Medicare Part B claims detail CMS PSPS · 2024

Calendar-year 2024 Medicare Part B fee-for-service activity for this HCPCS code, summed across all carriers, localities and specialties (CMS Physician/Supplier Procedure Summary). A “service” is one billed line/unit — not one claim — so counts run higher than claim counts.
Allowed charges
$0.00
Medicare paid
$0.00
Submitted services
50
Denial rate
100.0%
Submitted charges
$2.8K
Source: CMS Physician/Supplier Procedure Summary (PSPS), CY2024 — Medicare Part B carrier + DME fee-for-service claims (excludes Medicare Advantage). Figures are for the whole HCPCS code, which may cover uses beyond this drug. ⚠ CMS hides any figure covering fewer than 11 patients (a privacy rule), so totals — especially denials and low-volume codes — run a little low.

🗺️ Where J2281 is utilized

⏳
The geographic utilization map is building for this code — it aggregates millions of CMS Part B claim lines, then caches the result. Refresh in a moment; if it doesn’t appear, this code may have no reportable Part B utilization.

🗃️ Data sources & freshness

Every figure on this page is computed from public datasets. Here's what each section draws on and how current it is.
HCPCS code & descriptor
CMS HCPCS Level II code file
Loaded
Payment limit & billing unit
CMS Medicare Part B ASP Pricing File (quarterly)
Q3 2026 · as of 2026-08-20
NDC ↔ HCPCS crosswalk
CMS ASP NDC-HCPCS crosswalk + DMEPDAC (PDAC)
1 NDC mapped
NADAC acquisition cost
CMS National Average Drug Acquisition Cost (weekly)
Not available for mapped NDCs
Utilization & spend
CMS Part B Spending by Drug · PSPS · Physician & Other Practitioners
No reportable utilization
Figures are estimates for reference and may lag the source files. Always verify against the current CMS files and your payer's policy before submitting claims.

⚠️ Practical billing caveats

  • A crosswalk is not coverage. An NDC mapping or a published payment limit does not guarantee a payer will cover or pay this code. Check the specific plan's policy.
  • Units ≠ milligrams. Bill the number of HCPCS units (dose ÷ the code's unit size), not the milligram dose. Use the calculator above.
  • Discarded drug. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (and JZ when nothing is discarded) where the payer allows.
  • Rounding & partial units. Many payers require whole units; round per the payer's policy, not automatically up.
  • The code can cover more than this drug. Some HCPCS codes span multiple products or strengths — confirm the exact code for the product administered.
  • Figures lag. ASP limits change quarterly and utilization data are released with a delay. Verify against the current CMS files before billing.

❓ J2281 billing FAQ

What is HCPCS code J2281?
J2281 is a HCPCS Level II J-code used to bill Injection, moxifloxacin (fresenius kabi) not therapeutically equivalent to j2280, 100 mg under Medicare Part B and most medical (not pharmacy) benefits.
What is the billing unit for J2281?
One unit of J2281 represents 100 MG. Report the number of units equal to the dose administered divided by 100 MG.
How many units of J2281 should I bill?
Divide the dose administered by the code's unit size (100 MG) to get the number of billing units, then round per your payer's policy. The calculator on this page converts a dose into billing units and projects a full course.
How much does Medicare pay for J2281?
The Medicare Part B payment limit is $6.641 per unit (Q3 2026), based on ASP + 6%. After the 2% sequester the effective payment is about $6.508 per unit. Payment limits are revised quarterly.
Which NDCs bill under J2281?
1 NDC currently map to J2281 in the CMS ASP NDC-HCPCS crosswalk. See the NDC crosswalk table above for each product, package, billing units and estimated reimbursement.
Does a crosswalk mean J2281 is covered?
No. An NDC-to-HCPCS crosswalk and a published payment limit do not guarantee coverage or payment. Coverage depends on the payer, the diagnosis and the site of care — always verify the current policy before billing.
For professional billing reference only — verify against the current CMS files before submitting claims.