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Acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Capsule — RxCUI 1117245

RxNorm drug concept · Semantic clinical drug
RxCUI 1117245 Semantic clinical drug · SCD ● Current RxNorm concept 4 FDA products 4 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1117245
Official nameAcetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Capsule
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asAPAP 500 MG / diphenhydramine hydrochloride 25 MG Oral Capsule; acetaminophen 500 MG / diphenhydrAMINE HCl 25 MG Oral Capsule
FDA products mapped4
Package NDCs mapped4
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • You can use it for temporary relief of pain and itching from everyday skin problems — things like insect bites, minor burns, minor cuts and scrapes, and general skin irritations. I...
  • What can I actually use this cream or spray for?
  • You can apply it up to 3 to 4 times a day, but no more than that. More frequent use isn't going to help more — and the label is clear that you shouldn't exceed that limit. For kids...
  • This is really important — do not use this topical product at the same time as any other product that contains diphenhydramine, even a pill or capsule. That includes allergy medici...
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Acetaminophen 500 MG / diphenhydramine hydrochlo... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Capsule RxCUI 1117245

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 4

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Diphenhydramine 3498
    • Acetaminophen / diphenhydramine 214181
    • Diphenhydramine hydrochloride 1362
  2. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / diphenhydramine Oral Capsule 370519
    • Acetaminophen / diphenhydramine hydrochloride Oral Capsule 2646380
    • Acetaminophen / diphenhydramine Oral Product 1151204
    • Acetaminophen / diphenhydramine Pill 1151205
    • Acetaminophen / diphenhydramine hydrochloride Oral Product 2662609
    • Acetaminophen / diphenhydramine hydrochloride Pill 2662105
    • Oral Capsule 316965
    • Oral Product 1151131
    • +1 more in this family
  3. Clinical & branded drugs 2

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Acetaminophen 500 MG 315266
    • Diphenhydramine hydrochloride 25 MG 901813
  4. Packs 1

    Fixed collections of drugs packaged and sold together, like dose packs.

Showing up to 8 concepts per family — 15 of 16 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • {1 (acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG Oral Capsule) / 1 (acetaminophen 500 MG Oral Capsule) } Pack GPCK · 2738986
  • Acetaminophen 500 MG SCDC · 315266
  • Diphenhydramine hydrochloride 25 MG SCDC · 901813
  • Acetaminophen / diphenhydramine Oral Capsule SCDF · 370519
  • Acetaminophen / diphenhydramine hydrochloride Oral Capsule SCDFP · 2646380
  • Acetaminophen / diphenhydramine Oral Product SCDG · 1151204
  • Acetaminophen / diphenhydramine Pill SCDG · 1151205
  • Acetaminophen / diphenhydramine hydrochloride Oral Product SCDGP · 2662609
  • Acetaminophen / diphenhydramine hydrochloride Pill SCDGP · 2662105

📦 FDA Products & Package NDCs

4 products · 4 package NDCs
4 package NDCs map to RxCUI 1117245 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
55315-0988-24 24 CAPSULE in 1 BOTTLE (55315-988-24) Acetaminophen Diphenhydramine HCl FREDS, INC 2017-08-17
63941-0231-50 1 BOTTLE, PLASTIC in 1 BOX (63941-231-50) / 50 CAPSULE, GEL... PAIN RELIEVER PM Extra Strength Best Choice (Valu Merchandisers Company) 2013-03-08
84126-0375-01 1 BOTTLE in 1 CARTON (84126-375-01) / 100 CAPSULE, LIQUID F... Vicks PainQuil PM LIQUICAPS PAIN RELIEVER plus NIGHTTIME SLEEP-AID The Procter & Gamble Manufacturing Company 2026-03-17
84126-0377-20 1 KIT in 1 CARTON (84126-377-20) * 1 BOTTLE in 1 CARTON (8... Vicks PainQuil and Vicks PainQuil PM LIQUICAPS PAIN RELIEVER The Procter & Gamble Manufacturing Company 2026-03-17
Observed labelers: The Procter & Gamble Manufacturing Company (2) · Best Choice (Valu Merchandisers Company) (1) · FREDS, INC (1) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.