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Acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML Oral Solution — RxCUI 1294607

RxNorm drug concept · Semantic clinical drug
RxCUI 1294607 Semantic clinical drug · SCD ● Current RxNorm concept 2 FDA products 2 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1294607
Official nameAcetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML Oral Solution
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asAPAP 21.7 MG/ML / Diphenhydramine Hydrochloride 0.833 MG/ML Oral Solution; acetaminophen 650 MG / diphenhydrAMINE HCl 25 MG in 30 mL Oral Solution; APAP 325 MG / diphenhydramine hydrochloride 12.5 MG per 15 ML Oral Solution
FDA products mapped2
Package NDCs mapped2
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • You can use it for temporary relief of pain and itching from everyday skin problems — things like insect bites, minor burns, minor cuts and scrapes, and general skin irritations. I...
  • What can I actually use this cream or spray for?
  • You can apply it up to 3 to 4 times a day, but no more than that. More frequent use isn't going to help more — and the label is clear that you shouldn't exceed that limit. For kids...
  • This is really important — do not use this topical product at the same time as any other product that contains diphenhydramine, even a pill or capsule. That includes allergy medici...
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Acetaminophen 21.7 MG/ML / diphenhydramine hydro... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML Oral Solution RxCUI 1294607

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 4

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Diphenhydramine 3498
    • Acetaminophen / diphenhydramine 214181
    • Diphenhydramine hydrochloride 1362
  2. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / diphenhydramine Oral Solution 371897
    • Acetaminophen / diphenhydramine hydrochloride Oral Solution 2648062
    • Acetaminophen / diphenhydramine Oral Liquid Product 1151203
    • Acetaminophen / diphenhydramine Oral Product 1151204
    • Acetaminophen / diphenhydramine hydrochloride Oral Liquid Product 2660960
    • Acetaminophen / diphenhydramine hydrochloride Oral Product 2662609
    • Oral Solution 316968
    • Oral Liquid Product 1151137
    • +1 more in this family
  3. Clinical & branded drugs 2

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Acetaminophen 21.7 MG/ML 332581
    • Diphenhydramine hydrochloride 0.833 MG/ML 1294606
  4. Packs 1

    Fixed collections of drugs packaged and sold together, like dose packs.

Showing up to 8 concepts per family — 15 of 16 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

📦 FDA Products & Package NDCs

2 products · 2 package NDCs
2 package NDCs map to RxCUI 1294607 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00067-0105-08 245.5 mL in 1 BOTTLE (0067-0105-08) Theraflu Severe Cold Relief Nighttime Haleon US Holdings LLC 2023-12-01
00067-0107-01 1 KIT in 1 PACKAGE, COMBINATION (0067-0107-01) * 245.5 mL... Theraflu Severe Cold Relief Haleon US Holdings LLC 2024-02-01
Observed labelers: Haleon US Holdings LLC (2) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.