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Acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 1... — RxCUI 1659175

RxNorm drug concept · Semantic clinical drug
RxCUI 1659175 Semantic clinical drug · SCD ● Current RxNorm concept 1 FDA product 1 package NDC Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1659175
Official nameAcetaminophen 500 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 10 MG Powder for Oral Solution
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asacetaminophen 500 MG / diphenhydramine HCl 25 MG / phenylephrine HCl 10 MG Packet for Oral; acetaminophen 500 MG / diphenhydrAMINE HCl 25 MG / phenylephrine HCl 10 MG Powder for Oral Solution; acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 10 MG Granules for Oral Solution; APAP 500 MG / Diphenhydramine Hydrochloride 25 MG / Phenylephrine Hydrochloride 10 MG Powder for Oral Solution
FDA products mapped1
Package NDCs mapped1
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • You can use it for temporary relief of pain and itching from everyday skin problems — things like insect bites, minor burns, minor cuts and scrapes, and general skin irritations. I...
  • What can I actually use this cream or spray for?
  • You can apply it up to 3 to 4 times a day, but no more than that. More frequent use isn't going to help more — and the label is clear that you shouldn't exceed that limit. For kids...
  • This is really important — do not use this topical product at the same time as any other product that contains diphenhydramine, even a pill or capsule. That includes allergy medici...
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Acetaminophen 500 MG / diphenhydramine hydrochlo... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 500 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 10 MG Powder for Oral Solution RxCUI 1659175

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 6

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Diphenhydramine 3498
    • Phenylephrine 8163
    • Acetaminophen / diphenhydramine / phenylephrine 689785
    • Diphenhydramine hydrochloride 1362
    • Phenylephrine hydrochloride 8164
  2. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / diphenhydramine / phenylephrine Powder for Oral Solution 1804047
    • Acetaminophen / diphenhydramine hydrochloride / phenylephrine hydrochloride Powder for Oral Solution 2646362
    • Acetaminophen / diphenhydramine / phenylephrine Oral Powder Product 1804046
    • Acetaminophen / diphenhydramine / phenylephrine Oral Product 1151196
    • Acetaminophen / diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Powder Product 2662398
    • Acetaminophen / diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Product 2659765
    • Powder for Oral Solution 1540455
    • Oral Powder Product 1294711
    • +1 more in this family
  3. Clinical & branded drugs 3

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Acetaminophen 500 MG 315266
    • Diphenhydramine hydrochloride 25 MG 901813
    • Phenylephrine hydrochloride 10 MG 996705

Showing up to 8 concepts per family — 17 of 18 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Acetaminophen 500 MG SCDC · 315266
  • Diphenhydramine hydrochloride 25 MG SCDC · 901813
  • Phenylephrine hydrochloride 10 MG SCDC · 996705
  • Acetaminophen / diphenhydramine / phenylephrine Powder for Oral Solution SCDF · 1804047
  • Acetaminophen / diphenhydramine hydrochloride / phenylephrine hydrochloride Powder for Oral Solution SCDFP · 2646362
  • Acetaminophen / diphenhydramine / phenylephrine Oral Powder Product SCDG · 1804046
  • Acetaminophen / diphenhydramine / phenylephrine Oral Product SCDG · 1151196
  • Acetaminophen / diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Powder Product SCDGP · 2662398
  • Acetaminophen / diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Product SCDGP · 2659765

📦 FDA Products & Package NDCs

1 product · 1 package NDC
1 package NDC map to RxCUI 1659175 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00067-6801-02 6 POWDER in 1 CARTON (0067-6801-02) Theraflu Severe Cold relief Nighttime Haleon US Holdings LLC 2022-01-20
Observed labelers: Haleon US Holdings LLC (1) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.