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Acetaminophen 21.7 MG/ML / butalbital 3.33 MG/ML / caffeine 2.67 MG/ML Oral Solution — RxCUI 756245

RxNorm drug concept · Semantic clinical drug
RxCUI 756245 Semantic clinical drug · SCD ● Current RxNorm concept 1 FDA product 1 package NDC Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI756245
Official nameAcetaminophen 21.7 MG/ML / butalbital 3.33 MG/ML / caffeine 2.67 MG/ML Oral Solution
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asacetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG per 15 ML Syrup; butalbital 50 MG / acetaminophen 325 MG / caffeine 40 MG in 15 mL Oral Solution; acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG per 15 ML Elixir; APAP 21.7 MG/ML / butalbital 3.33 MG/ML / Caffeine 2.67 MG/ML Oral Solution
FDA products mapped1
Package NDCs mapped1
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Acetaminophen, Butalbital, and Caffeine: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • Yes, that's exactly what it's intended for. This combination of butalbital, acetaminophen, and caffeine is prescribed specifically to relieve tension headaches — the kind caused by...
  • What exactly is this medication for? My doctor prescribed it for headaches — is that normal?
  • This is actually something to be careful about. Butalbital, one of the ingredients, is habit-forming — meaning your body can become physically dependent on it if you take it freque...
  • Can I take this regularly if I get headaches a lot?
📖 Read our full Acetaminophen, Butalbital, and Caffeine guide →

🕸️ Concept Web — How Acetaminophen 21.7 MG/ML / butalbital 3.33 MG/ML... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 21.7 MG/ML / butalbital 3.33 MG/ML / caffeine 2.67 MG/ML Oral Solution RxCUI 756245

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 4

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Butalbital 19860
    • Caffeine 1886
    • Acetaminophen / butalbital / caffeine 214130
  2. Brand names 2

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Vanatol 1648579
    • Vtol 2261398
  3. Dose forms 12

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / butalbital / caffeine Oral Solution 452725
    • Acetaminophen / butalbital / caffeine Oral Liquid Product 1152254
    • Acetaminophen / butalbital / caffeine Oral Product 1152255
    • Acetaminophen / butalbital / caffeine Oral Solution [Vanatol] 1648581
    • Acetaminophen / butalbital / caffeine Oral Solution [Vtol] 2261400
    • Vanatol Oral Liquid Product 1648582
    • Vanatol Oral Product 1648583
    • Vtol Oral Liquid Product 2261401
    • +4 more in this family
  4. Clinical & branded drugs 7

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Acetaminophen 21.7 MG/ML 332581
    • Butalbital 3.33 MG/ML 604205
    • Caffeine 2.67 MG/ML 604206
    • Acetaminophen 21.7 MG/ML / butalbital 3.33 MG/ML / caffeine 2.67 MG/ML Oral Solution [Vanatol] 1648584
    • Acetaminophen 21.7 MG/ML / butalbital 3.33 MG/ML / caffeine 2.67 MG/ML Oral Solution [Vtol] 2261403
    • Acetaminophen 21.7 MG/ML / butalbital 3.33 MG/ML / caffeine 2.67 MG/ML [Vanatol] 1648580
    • Acetaminophen 21.7 MG/ML / butalbital 3.33 MG/ML / caffeine 2.67 MG/ML [Vtol] 2261399

Showing up to 8 concepts per family — 21 of 25 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Acetaminophen 21.7 MG/ML SCDC · 332581
  • Butalbital 3.33 MG/ML SCDC · 604205
  • Caffeine 2.67 MG/ML SCDC · 604206
  • Acetaminophen / butalbital / caffeine Oral Solution SCDF · 452725
  • Acetaminophen / butalbital / caffeine Oral Liquid Product SCDG · 1152254
  • Acetaminophen / butalbital / caffeine Oral Product SCDG · 1152255

Brand-Name Concepts

  • Acetaminophen 21.7 MG/ML / butalbital 3.33 MG/ML / caffeine 2.67 MG/ML Oral Solution [Vanatol] SBD · 1648584
  • Acetaminophen 21.7 MG/ML / butalbital 3.33 MG/ML / caffeine 2.67 MG/ML Oral Solution [Vtol] SBD · 2261403
  • Acetaminophen 21.7 MG/ML / butalbital 3.33 MG/ML / caffeine 2.67 MG/ML [Vanatol] SBDC · 1648580
  • Acetaminophen 21.7 MG/ML / butalbital 3.33 MG/ML / caffeine 2.67 MG/ML [Vtol] SBDC · 2261399
  • Acetaminophen / butalbital / caffeine Oral Solution [Vanatol] SBDF · 1648581
  • Acetaminophen / butalbital / caffeine Oral Solution [Vtol] SBDF · 2261400
  • Vanatol Oral Liquid Product SBDG · 1648582
  • Vanatol Oral Product SBDG · 1648583
  • Vtol Oral Liquid Product SBDG · 2261401
  • Vtol Oral Product SBDG · 2261402

📦 FDA Products & Package NDCs

1 product · 1 package NDC
1 package NDC map to RxCUI 756245 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
64950-0290-16 473 mL in 1 BOTTLE (64950-290-16) Butalbital, Acetaminophen and Caffeine Genus Lifesciences Inc. 2025-07-01
Observed labelers: Genus Lifesciences Inc. (1) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.