Can You Combine Flonase With Aleve-D?
In our latest question and answer, our pharmacist discusses whether or not it is safe to combine Flonase with Aleve-D.

Question
Can I take Aleve-D with Flonase?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated May 21, 2025
Key points
- There is no known drug interaction between the drugs contained in Aleve-D (naproxen; pseudoephedrine) and Flonase (fluticasone nasal spray).
Answer
Hello and thanks for your question!
Yes, it is safe to combine Aleve-D (naproxen; pseudoephedrine) with Flonase (fluticasone nasal spray). There is no known interaction between them.
All of the medications in question here (naproxen, pseudoephedrine, and fluticasone) are in different drug classes and work in different ways. They, for the most part, don't share common side effects either.
Additionally, even though we have two drugs here that can be used for nasal congestion (Flonase and pseudoephedrine), they can be combined, safely.
Flonase is a steroid, and although used often for nasal congestion, it is most effective when used on a consistent basis, generally for individuals who suffer allergies that result in congestion. It is actually more commonly used in those who suffer from allergies, versus congestion to due a cold and flu (which is what a product like Aleve-D is often used for).
Pseudoephedrine, on the other hand, has a more immediate impact and does not need to be used regularly for it to work. It should only be taken as needed when symptoms arise.
What Is Aleve-D?
Aleve-D consists of two drugs:
- Naproxen
- Pseudoephedrine
Naproxen is used to reduce fever and to relieve mild pain from headaches, muscle aches, arthritis, menstrual periods, the common cold, toothaches, and backaches. It is in a class of medications called NSAIDs and works by stopping the body's production of a substance that causes pain, fever, and inflammation.
Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure. It will relieve symptoms but will not treat the cause of the symptoms or speed recovery. It is in a class of medications called nasal decongestants and works by causing the narrowing of the blood vessels in the nasal passages.
What Is Flonase?
Fluticasone nasal spray (Flonase Allergy) is used to relieve symptoms of rhinitis such as sneezing and a runny, stuffy, or itchy nose and itchy, watery eyes caused by hay fever or other allergies (caused by an allergy to pollen, mold, dust, or pets).
Fluticasone is in a class of medications called corticosteroids. It works by blocking the release of certain natural substances that cause allergy symptoms.
Final Words
Thanks again for reaching out! Please feel free to do so again anytime!
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Dr. Brian Staiger, PharmD
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