Can You Cut Or Split Benadryl?

In our latest question and answer, the pharmacist discusses whether or not it is safe to cut or split Benadryl in half.

Question

Can you cut Benadryl in half?

Asked by Johnny On Aug 22, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Aug 22, 2022
Last updated Mar 28, 2024

Key points

  • Benadryl tablets can be cut but doing so will destroy the tablet coating. This may make them more difficult to swallow and have an unpleasant taste.

Answer

Benadryl (diphenhydramine) tablets can safely be cut or split in half. However, this regards the tablet dosage form only. Benadryl also comes in a liquid-gel dosage form which should not be cut, split, opened, or crushed.

Also, it is important to note 'Benadryl UltraTabs' have a wax coating on them, which makes them easier to swallow. Splitting these tablets will destroy the wax coating but won't affect how the medication works at all.

Always Ask Your Doctor Or Pharmacist About Splitting Tablets

It is always a good idea to check whether or not your medication can be safely cut or split. Many medications have "extended-release" properties and cutting them may destroy the release mechanism, potentially delivering the entire dose at one time, increasing the risk of side effects.

In addition, just because a medication is not extended release doesn't mean it is safe to cut. Many medications are extremely irritating to mucous membranes and the esophagus. One such example is Fosamax (alendronate). Lastly, some medications are cytotoxic or teratogenic and should not come into direct contact with the skin. An example here is the cytotoxic drug  Hydroxyurea.

As mentioned at the beginning of the answer, Benadryl tablets are considered safe to cut and split. They may also safely be crushed. If you are having problems with swallowing the tablets or need to alter your dosing, Benadryl is also available in liquid dosage forms.

About Benadryl

Benadryl (diphenhydramine) is a first-generation antihistamine, which works by blocking the binding of histamine to H1 receptors in our bodies. While effective for the treatment and prevention of allergies, it is commonly used as a nighttime sleep aid due to its sedating properties.

After taking Benadryl by mouth, it will begin to work in 30-60 minutes, with peak effects occurring around 90 minutes. Each dose will last between 4 and 6 hours, although it can last longer in certain individuals (e.g. the elderly).

References

  • Benadryl Manufacturer Website, Benadryl
  • Taste masking of bitter drug powder without loss of bioavailability by heat treatment of wax-coated microparticles., PubMed

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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