Can You Split Tramadol Tablets?
In our latest question and answer, the pharmacist discusses whether or not tramadol tablets can be split.

Question
Can I cut tramadol and take one and a half pieces?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 05, 2025
Key points
- Tramadol immediate-release tablets are safe to cut/split. Some have a score mark down the middle of the tablet to facilitate splitting.
- Extended-release tramadol products should not be cut, split or crushed.
Answer
Yes, most tramadol tablets can safely be cut or split in half. I wrote about this is another answer, which can be found here: Can You Cut Tramadol In Half?
It is important to point out that tramadol is a drug available in many different drug products and dosage forms. They can't all be safely cut in half. Only the immediate-release tablets can safely be split.
So, if you're doctor has instructed you to take one and one-half tablets of tramadol, just make sure you are taking the immediate-release tablets.
Only Split Immediate-Release Tramadol
As mentioned, tramadol comes in many forms, and only the immediate-release tablets can safely be split.
While some tramadol tablets have a score mark down the middle of the tablet to help facilitate splitting, most don't unfortunately. In fact, I don't believe any of the 50mg tablets have a score mark, only the 100mg tablets.
Nevertheless, as long as the tablets are immediate-release, you can split them. Below is an image of two different immediate-release tablets: a tramadol 100mg tablet with a score mark and a tramadol 50mg tablet without a score mark:
As a general rule of thumb, you shouldn't split, cut or crush any drug that is extended-release since doing so will cause the entire dose to be released at once, which greatly increases the risk of side effects. Examples of extended-release tramadol products include:
- ConZip (tramadol extended-release capsules)
- Ryzolt (tramadol extended-release tablets)
- Ultram ER (tramadol extended-release tablets)
None of these should be altered from their original form.
Final Words
I hope you found this informative! Reach back out anytime.
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Dr. Brian Staiger, PharmD
- 2617 views