Can You Take Bactrim With NyQuil?

In our latest question and answer, the pharmacist discusses if it is safe to combine Bactrim and NyQuil.

Question

I have an infection and my doctor gave me Bactrim. I am having issues sleeping at night and want to make sure it is safe to take NyQuil. Thanks in advance for your help.

Asked by Nany On Dec 09, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Dec 09, 2022
Last updated Apr 18, 2024

Key points

  • There is no known interaction between NyQuil and Bactrim. They are considered safe to take together.

Answer

Yes, it is safe to combine NyQuil and Bactrim (sulfamethoxazole-trimethoprim). There is no known drug interaction between them.

NyQuil represents an effective choice to help alleviate some of the symptoms you may be experiencing with an infection and can help you fall asleep at night due to its sedative effects.

Details

It's always a good idea to check into potential drug interactions between prescription and over-the-counter drugs, especially multi-ingredient ones like NyQuil.

There are a variety of different NyQuil products on the market, but the two most common are:

  • NyQuil
  • NyQuil Severe

NyQuil contains the following drugs:

  • Acetaminophen - Pain reliever
  • Dextromethorphan - Cough suppressant
  • Doxylamine - Sedating antihistamine

NyQuil Severe adds one additional drug, the nasal decongestant phenylephrine.

All of the drugs contained in NyQuil products are safe to take with Bactrim.

In fact, Bactrim is safe with most over-the-counter cough and cold medications. There is a minor interaction between it and some NSAIDs (like naproxen and ibuprofen), but it generally isn't thought to be overly clinically significant for most individuals. NyQuil does not contain an NSAID.

Final Words

Thanks for your question and I hope you found this helpful.

Reach back out anytime.

References

  • Sulfamethoxazole/Trimethoprim Monograph, PubChem
  • Considerations when prescribing trimethoprim–sulfamethoxazole, PubMed

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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