Can You Take Berberine If You Are On Zoloft?

In our latest question and answer, the pharmacist discusses the safety of taking berberine with Zoloft.


Hello there! My physician informed me that he didn't have the answer to this question, which is why I've come here. I'm on the verge of beginning a berberine supplement (specifically the brand Vitauthority). My rationale behind this is to assist with blood sugar issues and weight loss. Currently, I'm using Ocrevus for my Multiple Sclerosis, and I'm already aware that there are no interactions between berberine and Ocrevus. However, I'm also taking 50 mg of Zoloft every night. I'm curious if you could let me know whether there are any potential drug interactions between berberine and Zoloft. Online sources have provided conflicting information, and I'm uncertain if any interactions, if they exist, can be managed. I genuinely appreciate your help in advance!

Asked by Gen On Aug 08, 2023

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Aug 09, 2023
Last updated Jul 18, 2024

Key points

  • Berberine's mild inhibition of CYP3A4 enzyme might theoretically raise drug levels, but Zoloft's complex metabolism lowers the risk of a significant interaction.

Quick Answer

There is a theoretical interaction between berberine and Zoloft (sertraline) due to berberine's potential to affect drug metabolism through the CYP3A4 pathway—it has been reported to mildly inhibit the enzyme.

This inhibition of the enzyme could potentially raise the levels of drugs metabolized by CYP3A4, thus increasing the risk of adverse effects.

However, the risk of a significant interaction between berberine and Zoloft is lower because Zoloft is metabolized by multiple enzymes.

Detailed Answer

As previously mentioned, berberine has the potential to interact with Zoloft (sertraline) due to its impact on drug metabolism through the CYP3A4 enzyme pathway.

In vitro research (lab studies) and early clinical trials suggest that berberine may inhibit CYP3A4, an enzyme involved in metabolizing various drugs. This inhibition could potentially lead to increased levels of drugs metabolized by CYP3A4, thereby raising the risk of experiencing adverse effects associated with those drugs.

However, the concern regarding this interaction is mitigated by the fact that Zoloft's metabolism involves multiple enzymes, including CYP2B6, CYP2C19, CYP2C9, CYP3A4, and CYP2D6.

Because Zoloft relies on several enzymes for its metabolism, the inhibitory effect of berberine on CYP3A4 is less likely to significantly impact Zoloft concentrations.

Overall, given the multi-enzyme nature of Zoloft's metabolism, the risk of a substantial interaction between berberine and Zoloft is lower compared to situations where a drug heavily depends on CYP3A4 for metabolism.

Nevertheless, exercising prudence is advised. Consulting your healthcare provider before making changes to your medication regimen, especially when combining different medications or supplements, is crucial.

To ensure your well-being and the effectiveness of your treatment, it's recommended to engage in a discussion with your healthcare provider. They can provide personalized advice based on your medical history, current health status, and the specific medications you are taking.

Final Words

Thank you for reaching out! Please don't hesitate to do so again at any time.


  • The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers, PubMed
  • An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures, PubMed
  • Repeated administration of berberine inhibits cytochromes P450 in humans, PubMed
  • Zoloft Prescribing Information, AccessFDA

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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