Can You Take Benadryl With Amoxicillin?

In our latest question and answer, the pharmacist discusses whether or not Benadryl (diphenhydramine) and amoxicillin are safe to take together.


Is Benadryl safe to take with amoxicillin?

Asked by Jerry On Aug 31, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Aug 31, 2022
Last updated Sep 30, 2023

Key points

  • There is no known interaction between Benadryl and amoxicillin. They are considered safe to take together.


Benadryl and amoxicillin have no drug interactions and are safe to take together.

In fact, there may be situations where Benadryl and amoxicillin are recommended to take together to treat symptoms from infection such as insomnia, congestion, and post-nasal drip. You can feel safe combinging them.

Amoxicillin Information

Amoxicillin is an aminopenicillin antibiotic. It has a broader spectrum of action (i.e. effective for more types of infection) than penicillin and is generally well tolerated when compared to other antibiotics.

Amoxicillin is indicated for the treatment of a variety of infections including otitis media (ear infection), upper respiratory infections, and urinary tract infections (UTIs).

Amoxicillin is generally taken for 10 to 14 days and can be given without regard to food in most cases. Outside of the potential for allergic reaction with amoxicillin, the most common side effects are:

  • Diarrhea
  • Headache
  • Nausea

Benadryl (Diphenhydramine) Information

Benadryl is a first-generation antihistamine, which typically have a relatively short duration of action (around 4 to 8 hours) and are known to cause sedation. In addition to its use for treating seasonal allergy symptoms such as a runny nose and watery eyes, Benadryl is also effective for treating symptoms of nausea, vomiting, and vertigo associated with motion sickness.

As Benadryl has fairly significant sedating effects, it is very often used as a nighttime sleep aide. in fact, it is a common ingredient in over-the-counter sleep products, such as ZzzQuil.

Benadryl will begin working in about 20 to 30 minutes after taking a dose by mouth and maximum blood concentrations are reached after 1 to 2 hours. The duration of action varies by individual but generally lasts 4 to 6 hours. It is known to last longer in older adults and the elderly.

Benadryl is generally well tolerated but can cause the following side effects:

  • Sedation
  • Dizziness
  • Dry mouth
  • Dry eyes
  • Constipation

Final Words

Thanks again for reaching out! You can feel safe taking Benadryl and amoxicillin together. Please be sure to reach back out to us if anything us comes up for you!


About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at! You can also connect with Dr. Brian Staiger on LinkedIn.

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