Can You Take Benadryl With Hyland's Products?

Answer

There is no known interaction between Hyland's Cough & Mucus and Benadryl. They are considered safe to take together.

Most Hyland's products, including the one you mentioned in your question, are homeopathic, and contain only very small amounts of their listed ingredients. Due to this, homeopathic products are generally free of clinically significant drug interactions.

What Is In Hyland's Cough & Mucus?

You didn't mention in your question if you are asking about the daytime or nighttime formula of Hyland's Cough & Mucus. Nevertheless, there is no data to suggest Benadryl interacts with either of them, even the nighttime formula.

Hyland's Cough & Mucus Daytime contains the following ingredients:

• Antimonium Tartaricum 15X HPUS
• Bryonia Alba 15X HPUS
• Ferrum Phosphoricum 12X HPUS
• Hepar Sulph Calc 12X HPUS
• Ipecacuanha 12X HPUS
• Phosphorus 15X HPUS
• Pulsatilla 12X HPUS
• Rumex Crispus 6X HPUS
• Citric Acid
• Glycerine
• Glycyrrhiza Extract
• Natural Grape Flavor
• Purified Water
• Sodium Benzoate

Hyland's Cough & Mucus Nighttime contains the following ingredients:

• Antimonium Tartaricum 15X HPUS
• Bryonia Alba 15X HPUS
• Chamomilla 6X HPUS
• Ferrum Phosphoricum 12X HPUS
• Hepar Sulph Calc 12X HPUS
• Hydrastis Canadensis 15X HPUS
• Ipecacuanha 12X HPUS
• Phosphorus 15X HPUS
• Pulsatilla 12X HPUS
• Rumex Crispus 6X HPUS
• Citric Acid
• Glycerine
• Glycyrrhiza Extract
• Natural Grape Flavor
• Purified Water
• Sodium Benzoate

You can see that both products contain very similar ingredients, with the nighttime formulation only adding 'chamomilla' and 'hydrastis canadensis'.

All of the ingredients in these products are homeopathic, which utilizes the principle of 'like cures like'. In other words, homeopathic products use small amounts of ingredients that in larger doses, would cause the symptoms that are being treated.

The 6X and 12X indicates the level of dilution (e.g., a 6X dilution indicates a 1:1,000,000 dilution). There are only very, very small amounts of active ingredients in these preparations. 

None of the ingredients in either of these Hyland's products are known to interact with Benadryl (diphenhydramine).

Generally, you want to avoid combining Benadryl with other products intended for nighttime use to avoid additive sedative effects. However, in this case, due to Hyland's being a homeopathic product and the ingredients being in such small amounts, it likely has only a mild sedative effect (if at all).

Final Words

Thanks so much for your question and reach back out anytime!