Adderall With Azithromycin Interaction Details

In our latest question and answer, our pharmacist discusses whether or not there is a drug interaction between Adderall and azithromycin

Question

I have an upper respiratory tract infection and got a Zpack. I take Adderall every day. Are they okay together?

Asked by Whitney On Oct 17, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Oct 17, 2022
Last updated Mar 28, 2024

Key points

  • There is no known drug interaction between Adderall (amphetamine; dextroamphetamine) and a Z-Pack.

Answer

There is no known drug interaction between a Z-pack (azithromycin) and Adderall (amphetamine; dextroamphetamine). They are considered safe to take together.

However, it is important to note that they should be used cautiously together if you have been diagnosed with heart rhythm problems. Both drugs can increase the risk of 'QT prolongation, a type of arrhythmia. The risk of this occurring if you have not been diagnosed with a heart rhythm problem before, and have no risk factors, is low.

About Azithromycin

Azithromycin is used to treat certain bacterial infections, such as bronchitis; pneumonia; sexually transmitted diseases (STD); and infections of the ears, lungs, sinuses, skin, throat, and reproductive organs.

Azithromycin is in a class of medications called macrolide antibiotics and works by stopping the growth of bacteria by binding to the 50S subunit of bacterial ribosomes. This leads to the inhibition of bacterial protein synthesis.

About Adderall

The combination of dextroamphetamine and amphetamine is used as part of a treatment program to control symptoms of attention deficit hyperactivity disorder.

Both amphetamine and dextroamphetamine are central nervous system stimulants, which work by changing the amounts of certain natural substances (e.g. norepinephrine, dopamine and serotonin) in the brain.

Final Words

Thank you for reaching out!

References

  • Azithromycin Monograph, PubChem
  • Dextroamphetamine Monograph, PubChem
  • Azithromycin Prescribing Information, AccessFDA

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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