Is Tylenol Safe To Take With Eliquis?
In our latest question and answer, our pharmacist discusses whether or not Tylenol (acetaminophen) is safe to take with Eliquis.
I was recently put on Eliquis for a pulmonary embolism. I have very mild arthritis that I usually just take Tylenol for. Is that safe to take with Eliquis?
Aug 29, 2022- Tylenol is safe to take with Eliquis and is the preferred over-the-counter pain reliever for people on this blood thinner.
- Avoid NSAIDs like ibuprofen and naproxen when taking Eliquis because they increase the risk of serious bleeding, especially in the stomach.
- Also avoid aspirin unless your doctor specifically recommends it, and limit alcohol while taking Eliquis.
Answer
Thanks for reaching out to us!
Tylenol (acetaminophen) is a safe pain reliever to take with Eliquis (apixaban). In fact, Tylenol is the preferred pain reliever to take when compared to the other options available over the counter, like NSAIDs.
NSAIDs, which include drugs like Advil (ibuprofen) and Aleve (naproxen) are not recommended to take with Eliquis due to the increased risk of bleeding, which can be serious (especially gastrointestinal bleeding). This interaction occurs due to the additive anticoagulant effects of Eliquis and NSAIDs. Tylenol does not carry this risk.
Take Steps To Minimize The Risk Of Bleeding
As mentioned, if you need a pain reliever while taking Eliquis, Tylenol is the preferred option since it lacks anticoagulant (i.e. blood-thinning) effects.
Some individuals may benefit from additional measures to decrease the risk of bleeding while taking Eliquis. This includes:
- Adding a proton pump inhibitor (e.g. Prilosec, Prevacid, etc.) in those with a history of gastrointestinal bleeds or ulcers, and in those over 75 years old.
- Avoid aspirin (unless specifically recommended by your doctor)
- Avoid excess alcohol intake
- Ensure blood pressure is under control
- Follow the directions provided if you are undergoing surgery
Final Words
Thanks again for your question! We are always more than happy to help out, so please contact us again if anything else comes up!
About Eliquis
Eliquis (apixaban) is used to help prevent strokes or blood clots in people who have atrial fibrillation (a condition in which the heart beats irregularly, increasing the chance of clots forming in the body and possibly causing strokes) that is not caused by heart valve disease. It is also used to prevent deep vein thrombosis (DVT; a blood clot, usually in the leg) and pulmonary embolism (PE; a blood clot in the lung) in people who are having hip replacement or knee replacement surgery.
Apixaban is in a class of medications called factor Xa inhibitors. It works by blocking the action of a certain natural substance that helps blood clots to form.
About Tylenol
Tylenol (acetaminophen) is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever. Acetaminophen may also be used to relieve the pain of osteoarthritis (arthritis caused by the breakdown of the lining of the joints).
Tylenol is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body.
References & sources
- Association of Oral Anticoagulants and Proton Pump Inhibitor Cotherapy With Hospitalization for Upper Gastrointestinal Tract Bleeding. — PubMed
- Gastroprotection in patients on antiplatelet and/or anticoagulant therapy: a position paper of National Association of Hospital Cardiologists (ANMCO) and the Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO) — PubMed
- Eliquis Prescribing Information — AccessFDA
Glossary — Terms in This Answer
- NSAIDs
- A group of pain-relieving medications like ibuprofen and naproxen that can increase bleeding risk when taken with blood thinners.
- Anticoagulant
- A medication or substance that prevents blood from clotting or thins the blood to reduce clot formation.
- Gastrointestinal bleeding
- Bleeding that occurs in the stomach or intestines, which can be a serious side effect of certain drug combinations.
- Atrial fibrillation
- A heart condition where the heart beats irregularly, increasing the risk of blood clots forming in the body.
- Deep vein thrombosis
- A blood clot that forms in a deep vein, usually in the leg, which can be dangerous if it travels to the lungs.
- Pulmonary embolism
- A blood clot that lodges in the lungs, blocking blood flow and potentially causing serious harm.
- Factor Xa inhibitors
- A class of blood-thinning medications that work by blocking a natural substance needed for blood clots to form.
- Proton pump inhibitor
- A medication that reduces stomach acid and can help prevent gastrointestinal bleeding in people at high risk.