Can You Take Amoxicillin With Entresto?
In our latest question and answer, the pharmacist discusses whether or not there is a drug interaction between Entresto and amoxicillin.
I have been taking Entresto for about a year. My dentist wants to give me amoxicillin for a dental procedure. Safe to take together?
Dec 04, 2022- Entresto and amoxicillin are safe to take together with no known interaction between them.
- Amoxicillin is an antibiotic used to treat bacterial infections including ear, nose, throat, urinary tract, and skin infections.
- Entresto is a heart failure medication containing two drugs that work together to lower the risk of death and hospitalization in certain heart failure patients.
Answer
There is no known interaction between Entresto and amoxicillin. They are considered safe to take together.
I appreciate you reaching out! It's always a good idea to look into potential drug interactions, especially when drugs are being prescribed by two different providers.
Additionally, I imagine you are being prescribed amoxicillin by your dentist because you are at 'high risk' for infective endocarditis. Antibiotic prophylaxis is generally recommended for some individuals with certain cardiac conditions. This is a topic we've written about before (which can be found here).
With you likely being more at risk to complications due to your health condition, it's especially important that you look out for dangerous drug interactions.
As mentioned though, Entresto is considered safe with amoxicillin.
What Is Entresto?
Entresto contains two drugs, valsartan and sacubitril, and is usually used in combination with other medications to lower the risk of death and hospitalization in adults with certain types of heart failure.
Valsartan is in a class of medications called angiotensin II receptor antagonists and works by blocking the action of certain natural substances that tighten the blood vessels, allowing the blood to flow more smoothly and the heart to pump more efficiently.
Sacubitril is in a class of medications called neprilysin inhibitors and works to help control blood volume.
What Is Amoxicillin?
Amoxicillin is an 'aminopenicillin' used to treat certain infections caused by bacteria, such as pneumonia; bronchitis (infection of the airway tubes leading to the lungs); and infections of the ears, nose, throat, urinary tract, and skin.
Amoxicillin is in a class of medications called penicillin-like antibiotics and works by stopping the growth of bacteria.
Final Words
Thanks so much for reaching out and please do so again anytime!
Glossary — Terms in This Answer
- Infective endocarditis
- A serious infection of the heart's inner lining that can occur when bacteria enter the bloodstream.
- Antibiotic prophylaxis
- Taking antibiotics before a procedure to prevent a bacterial infection from developing.
- Valsartan
- A medication that relaxes blood vessels to help lower blood pressure and reduce heart strain.
- Sacubitril
- A medication that helps the body reduce excess fluid and ease the workload on the heart.
- Angiotensin II receptor antagonists
- A class of drugs that blocks natural substances in the body that tighten blood vessels.
- Neprilysin inhibitors
- A class of drugs that work by preventing the breakdown of certain proteins that help control fluid balance in the body.
- Aminopenicillin
- A type of penicillin-based antibiotic effective against a wide range of bacterial infections.
- Penicillin-like antibiotics
- A class of antibiotics derived from or similar to penicillin that kill bacteria by preventing them from forming cell walls.
Dr. Brian Staiger, PharmD
Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified
Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...
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