Can You Take Benadryl (Diphenhydramine) With Tylenol?

Answer

Hi there and thanks for reaching out! Yes, Benadryl (diphenhydramine) may be safely taken with Tylenol (acetaminophen) as there is no drug interaction between the two. In fact, these two drugs can often be found together in the same product.

For one example, both of the active ingredients are in the product Tylenol PM, which is used to relieve pain while helping to fall asleep faster.

The product image below is the packaging for Tylenol PM, which shows it contains both acetaminophen and diphenhydramine:

One dose (two caplets) of Tylenol PM, contains:

• 1000 mg of acetaminophen
• 50 mg of diphenhydramine

So, whether or not you take Tylenol and Benadryl together as separate drugs, or in a product that already contains them both, they are considered safe together. They also don't share many similar side effects, so the combination is generally safe in that regard as well. 

About Tylenol

Tylenol (acetaminophen) is an analgesic over-the-counter medication used to treat fever and pain related to headaches, backaches, toothaches, wounds, or arthritis.

Tylenol is in many over-the-counter pain, migraine, and cold/cough medications. Regular strength Tylenol is sold as 325 mg of acetaminophen, extra strength has 500 mg of acetaminophen, and Tylenol Arthritis has 650mg.

The active ingredient in Tylenol, acetaminophen, is also sold in some prescription pain medications like Tylenol with Codeine, Vicodin, and Percocet.

In general, it is not recommended for someone to take acetaminophen on a daily basis because it can cause liver toxicity when taken in a consistent manner, especially if taken with alcohol or illicit drugs.

Final Words

Thanks so much for reaching out to us!