Is Elderberry Safe With Amoxicillin?

In our latest question and answer, the pharmacist discusses whether or not amoxicillin is safe to take with elderberry.

3 min read Updated Jun 2026 Read by 6,639 people
Is Elderberry Safe With Amoxicillin?
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Holly asked

I have a sinus infection and was just put on amoxicillin. I've heard elderberry supplements can help me get better faster. Is it okay to take with amoxicillin?

Jul 09, 2022
The quick answer
  • Elderberry and amoxicillin are safe to take together with no known interactions between them.
  • Elderberry is considered generally recognized as safe by the FDA and has no known drug interactions with most antibiotics.
  • Amoxicillin is an antibiotic used to treat bacterial infections and will not work for colds, flu, or other viral infections.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.
Medications in this answer — tap to explore

Hello and thanks for reaching out to us! I can certainly understand wanting to take a supplement that will help you feel better faster!

The good news here is that there are no known or expected interactions between amoxicillin and elderberry. They are considered safe to take together.

It is always a little challenging to evaluate dietary supplements for drug interactions due to the lack of studies, but elderberry is one of the more well-studied ones. There is nothing to indicate it interferes with amoxicillin and vice versa.

So, if you are experiencing cold or flu symptoms, and you want to take a supplement that contains elderberry in an effort to try and feel better sooner, elderberry appears to be safe.

What Is Elderberry?

Elderberry has a long history of use medically for its purported immune system-enhancing effects. It is mostly marketed in over-the-counter supplements to help shorten the duration of colds and the flu.

Although there have been relatively few studies testing how well it works in this regard, some small clinical studies have shown it can affect different components of the immune system (e.g. cytokines) and may have positive benefits in healthy adults and children. Other studies have shown no benefit, however. More rigorous studies are needed to better understand exactly the benefits it can have as a supplement.

Regardless, elderberry seems relatively safe to use in amounts that would commonly be found in food. In fact, it is 'generally recognized as safe' (GRAS) by the FDA.

There are no known drug interactions between elderberry and prescription or over-the-counter medications.

Based on studies showing that it may have immunostimulating effects, it theoretically could interact with immunosuppressants, but this has not been shown clinically. Regardless, simply due to the lack of available information, it should not be combined with drugs that work by suppressing the immune system.

What Is Amoxicillin?

Amoxicillin is used to treat certain infections caused by bacteria, such as pneumonia; bronchitis (infection of the airway tubes leading to the lungs); and infections of the ears, nose, throat, urinary tract, and skin. It is also used in combination with other medications to eliminate H. pylori, a bacterium that causes ulcers.

Amoxicillin is in a class of medications called penicillin-like antibiotics. It works by stopping the growth of bacteria. It will not work for colds, flu, and other viral infections.

Other Antibiotics?

Just like with amoxicillin, studies indicate that elderberry is safe to take with most antibiotics (i.e. has no drug interaction). This includes antibiotics like:

  • Penicillin
  • Augmentin
  • Bactrim
  • Keflex
  • Clindamycin
  • Levaquin
  • Ciprofloxacin
  • Doxycycline

Final Words

Thanks again for reaching out to us!

References & sources
  1. Amoxicillin Monograph — PubChem
  2. Amoxil Prescribing Information — AccessFDA
  3. Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials — PubMed
Glossary — Terms in This Answer
Amoxicillin
An antibiotic medication that belongs to the penicillin family and is used to treat bacterial infections in various parts of the body.
Dietary supplements
Products taken by mouth that contain vitamins, minerals, herbs, or other substances intended to supplement the diet and support health.
Drug interactions
Changes in how a medication works or behaves in the body when taken together with another drug or substance.
Cytokines
Signaling molecules produced by immune cells that help coordinate and regulate immune system responses.
Immunosuppressants
Medications that reduce or suppress the activity of the immune system.
H. pylori
A type of bacteria that infects the stomach and can cause ulcers and digestive problems.
Penicillin-like antibiotics
A class of antibiotic drugs similar in structure and function to penicillin that kill bacteria by stopping their growth.
Viral infections
Illnesses caused by viruses rather than bacteria, such as colds and flu, which antibiotics cannot treat.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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