Can You Take Gabapentin And Nexium Together?

In our latest question and answer, the pharmacist discusses whether or not there is a drug interaction between gabapentin and Nexium.


Can you take gabapentin and Nexium together?

Asked by Cindy On Oct 12, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Oct 12, 2022
Last updated Oct 12, 2022

Key points

  • There is no drug interaction between gabapentin and Nexium (esomeprazole). They can safely be taken together.
  • Be sure to take Nexium at least 30 minutes before a meal for best effect.


Hello and thanks for your question!

There is no known drug interaction between gabapentin and Nexium (esomeprazole). They are considered safe to take together.

However, it is important to note that for optimal effect, PPIs (proton pump inhibitors) like Nexium should be taken 30 to 60 minutes before a meal. You can take it with many other drugs (like gabapentin) but be sure to take food into consideration here since some individuals like to take gabapentin with food to reduce the incidence of certain side effects, like nausea.

So, if you do decide to take Nexium and gabapentin together, be sure to do so at least 30 minutes before a meal. If you like to take your gabapentin with food, you should separate it from Nexium.

About Gabapentin

Gabapentin capsules, tablets, and oral solution are used along with other medications to help control certain types of seizures in people who have epilepsy. Gabapentin capsules, tablets, and oral solution are also used to relieve the pain of postherpetic neuralgia (PHN; the burning, stabbing pain or aches that may last for months or years after an attack of shingles).

Gabapentin is in a class of medications called anticonvulsants and works to treat seizures by decreasing abnormal excitement in the brain. For pain, gabapentin works by changing the way the body senses it. It is not known exactly how gabapentin works to treat restless legs syndrome.

About Nexium

Prescription esomeprazole is used to treat the symptoms of gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and possible injury of the esophagus (the tube between the throat and stomach) in adults and children 1 year of age and older.

Nonprescription (over the counter) esomeprazole is used to treat frequent heartburn (heartburn that occurs at least 2 or more days a week) in adults.

Esomeprazole is in a class of medications called proton pump inhibitors and works by decreasing the amount of acid made in the stomach.

Final Words

Thanks again for contacting us!


  • PPIs Are Better Taken Before Meals, NEJM Journal Watch
  • Proton pump inhibitors: better acid suppression when taken before a meal than without a meal, PubMed

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Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at! You can also connect with Dr. Brian Staiger on LinkedIn.

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