Can You Take Macrobid With Famotidine And Pantoprazole?
In our latest question and answer, the pharmacist discusses taking Macrobid, Pepcid and Protonix together.

Question
I’m taking famotidine 40mg tablets and pantoprazole 40mg. Can I take nitrofurantoin mono/mac 100mg caps for UTI?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 02, 2025
Key points
- There is no known interaction between any of the medications in question.
Quick Answer
There is no known interaction between Macrobid (Nitrofurantoin Monohydrate/Macrocrystals), Protonix (pantoprazole), and Pepcid (famotidine). They are considered safe to take together.
Detailed Answer
Nitrofurantoin Monohydrate/Macrocrystals, commonly known by the brand name Macrobid, is an antibiotic frequently prescribed for urinary tract infections (UTIs). It works by killing bacteria in the urinary tract.
Regarding the co-administration of Pepcid (famotidine), Protonix (pantoprazole), and Macrobid (Nitrofurantoin mono/Mac), they are all generally considered safe to take together.
Macrobid absorption is not significantly affected by stomach pH (which Pepcid and Protonix alter) and neither Protonix nor Pepcid affects the metabolism of Macrobid in any way.
It should be noted that studies have found that although Macrobid can be taken with or without food, taking it with food can help make it better tolerated. Just a helpful tidbit for you.
Final Words
I hope this answer helped! Thanks for reaching out!
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Dr. Brian Staiger, PharmD
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