Can You Take Macrobid With Famotidine And Pantoprazole?
In our latest question and answer, the pharmacist discusses taking Macrobid, Pepcid and Protonix together.
I’m taking famotidine 40mg tablets and pantoprazole 40mg. Can I take nitrofurantoin mono/mac 100mg caps for UTI?
Jun 24, 2023- There is no known interaction between Macrobid, famotidine, and pantoprazole, so they are safe to take together.
- Macrobid absorption is not significantly affected by the stomach acid changes caused by famotidine or pantoprazole.
- Taking Macrobid with food can help improve how well you tolerate it.
Quick Answer
There is no known interaction between Macrobid (Nitrofurantoin Monohydrate/Macrocrystals), Protonix (pantoprazole), and Pepcid (famotidine). They are considered safe to take together.
Detailed Answer
Nitrofurantoin Monohydrate/Macrocrystals, commonly known by the brand name Macrobid, is an antibiotic frequently prescribed for urinary tract infections (UTIs). It works by killing bacteria in the urinary tract.
Regarding the co-administration of Pepcid (famotidine), Protonix (pantoprazole), and Macrobid (Nitrofurantoin mono/Mac), they are all generally considered safe to take together.
Macrobid absorption is not significantly affected by stomach pH (which Pepcid and Protonix alter) and neither Protonix nor Pepcid affects the metabolism of Macrobid in any way.
It should be noted that studies have found that although Macrobid can be taken with or without food, taking it with food can help make it better tolerated. Just a helpful tidbit for you.
Final Words
I hope this answer helped! Thanks for reaching out!
References & sources
Glossary — Terms in This Answer
- Antibiotic
- A medication that kills bacteria or stops them from growing to treat infections.
- Urinary tract infections (UTIs)
- Infections that occur in the bladder, urethra, or other parts of the urinary system.
- Absorption
- The process by which a medication enters the bloodstream from the digestive system.
- Stomach pH
- The level of acidity in the stomach, which affects how quickly medications dissolve and are absorbed.
- Metabolism
- The process by which the body breaks down and processes a medication.
- Co-administration
- Taking two or more medications at the same time together.
Dr. Brian Staiger, PharmD
Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified
Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...
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