Can You Take Meloxicam And Advil Together?
In our latest question and answer, our pharmacist discusses whether or not it is safe to take meloxicam and Advil (ibuprofen) together.

Question
I wrote the other day about meloxicam and an interaction. I want to know now if it is okay to take meloxicam and Advil together.

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated May 10, 2025
Key points
- Advil (ibuprofen) and meloxicam should not be taken together. Both drugs are in the same class and combining them will increase the risk of side effects.
Answer
There is an interaction between meloxicam (generic for Mobic) and Advil (ibuprofen). Both drugs are NSAIDs, and taking both would be considered a therapeutic duplication, which increases the risk of side effects with little to no additional pain-relieving benefit.
Concerns Taking Both Together
As stated, Advil (ibuprofen) and meloxicam are in the same drug class and are classified as NSAIDs (non-steroidal anti-inflammatory drugs).
Combining multiple non-steroidal anti-inflammatory agents has the potential to increase the risk of adverse effects including:
- Gastrointestinal bleeding
- Kidney dysfunction
- Increase in blood pressure
- Increased risk of heart attack
Studies have not shown that taking two NSAIDs provides any benefit over single-agent therapy.
The only real exception to taking two NSAIDs together is when your doctor prescribes aspirin for cardioprotection. There may be cases where adding on an additional NSAID to aspirin for pain relief is warranted.
Alternatives
Instead of taking two NSAIDs, you should explore other options for pain relief, which include adjusting the dose of one NSAID or adding on an additional drug, such as Tylenol (acetaminophen).
Final Words
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References
- Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage., PubMed
- Meloxicam Monograph, PubChem
- Ibuprofen Monograph, PubChem
- NSAID use selectively increases the risk of non-fatal myocardial infarction: a systematic review of randomised trials and observational studies., PubMed
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Dr. Brian Staiger, PharmD
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