Can You Take Tylenol With A Medrol Dose Pack?
In our latest question and answer, the pharmacist discusses whether or not it is safe to take Tylenol with a Medrol dose Pack.

Question
Hello, I actually just asked a question but I meant to ask about the Medrol dose pack and Tylenol. I think that is different than prednisone.

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 20, 2025
Key points
- There is no known drug interaction between Tylenol (acetaminophen) and a Medrol Dose Pack (methylprednisolone).
Answer
Thanks for reaching out again!
Yes, it is safe to combine Tylenol and methylprednisolone (the drug in the Medrol Dose Pack). There is no known interaction between them.
As mentioned in my other answer, Tylenol is more often than not the preferred pain reliever to take with corticosteroids, like methylprednisolone. Others, like ibuprofen, interact with it and need to be used cautiously.
What Is Methylprednisolone
Methylprednisolone, a corticosteroid, is similar to a natural hormone produced by your adrenal glands. It is often used to replace this chemical when your body does not make enough of it. It relieves inflammation (swelling, heat, redness, and pain) and is used to treat certain forms of arthritis; skin, blood, kidney, eye, thyroid, and intestinal disorders (e.g., colitis); severe allergies; and asthma. Methylprednisolone is also used to treat certain types of cancer and is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
What Is Tylenol
Acetaminophen is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever. It may also be used to relieve the pain of osteoarthritis (arthritis caused by the breakdown of the lining of the joints).
Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body.
Final Words
Thanks again for reaching out and please do so again if anything else comes up!
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Dr. Brian Staiger, PharmD
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