Can You Take Tylenol With A Medrol Dose Pack?

In our latest question and answer, the pharmacist discusses whether or not it is safe to take Tylenol with a Medrol dose Pack.

Question

Hello, I actually just asked a question but I meant to ask about the Medrol dose pack and Tylenol. I think that is different than prednisone.

Asked by Liz On Jul 16, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Jul 16, 2022
Last updated Apr 17, 2024

Key points

  • There is no known drug interaction between Tylenol (acetaminophen) and a Medrol Dose Pack (methylprednisolone).

Answer

Thanks for reaching out again!

Yes, it is safe to combine Tylenol and methylprednisolone (the drug in the Medrol Dose Pack). There is no known interaction between them.

As mentioned in my other answer, Tylenol is more often than not the preferred pain reliever to take with corticosteroids, like methylprednisolone. Others, like ibuprofen, interact with it and need to be used cautiously.

What Is Methylprednisolone

Methylprednisolone, a corticosteroid, is similar to a natural hormone produced by your adrenal glands. It is often used to replace this chemical when your body does not make enough of it. It relieves inflammation (swelling, heat, redness, and pain) and is used to treat certain forms of arthritis; skin, blood, kidney, eye, thyroid, and intestinal disorders (e.g., colitis); severe allergies; and asthma. Methylprednisolone is also used to treat certain types of cancer and is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What Is Tylenol

Acetaminophen is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever. It may also be used to relieve the pain of osteoarthritis (arthritis caused by the breakdown of the lining of the joints).

Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body.

Final Words

Thanks again for reaching out and please do so again if anything else comes up!

References

  • Acetaminophen Monograph, PubChem
  • Methylprednisolone Monograph, PubChem

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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