Can You Take Tylenol With Sudafed?

In our latest question and answer, the pharmacist discusses whether or not Tylenol can safely be taken with Sudafed (pseudoephedrine).


Hello! I have a nasty sinus headache and want to know if it is safe to take Tylenol and Sudafed together. I have both in my medicine cabinet.

Asked by Sophie On Jul 20, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Jul 20, 2022
Last updated Jul 20, 2022

Key points

  • Tylenol and Sudafed are safe to take together. There is no interaction between them.


Hello and thanks for reaching out! I'm sorry to hear you're dealing with a sinus headache. We're more than happy to provide some guidance.

Tylenol (acetaminophen) and Sudafed (pseudoephedrine) are perfectly safe to take together. There is no drug interaction between them.

In fact, before pseudoephedrine went 'behind the counter' and required identification before being purchased (due to the stipulations outlined in the Combat Methamphetamine Epidemic Act (CMEA)), you could regularly find products that contained both acetaminophen and pseudoephedrine in a single product. These products included:

  • Tylenol Sinus
  • Ornex
  • Sudafed Sinus and Cold

Most of these products have been discontinued, or have had pseudoephedrine replaced with another decongestant, phenylephrine, which allows them to stay on pharmacy shelves. You can still find pseudoephedrine in combination with other pain relievers, like ibuprofen (e.g.Advil Cold and Sinus) though.

So, going back to your question, to reiterate, Tylenol and Sudafed are okay to take together and do not interfere with one another. I don't think you'll be able to find a single product that contains both anymore, but it's not a problem to just take them separately.

About Tylenol

Tylenol (acetaminophen) is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever. It may also be used to relieve the pain of osteoarthritis (arthritis caused by the breakdown of the lining of the joints).

Tylenol is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body.

About Sudafed

Sudafed (pseudoephedrine) is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure. It will relieve symptoms but will not treat the cause of the symptoms or speed recovery.

Sudafed is in a class of medications called nasal decongestants. It works by causing narrowing of the blood vessels in the nasal passages.


About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 11 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Feel free to send him an email at! You can also connect with Dr. Brian Staiger on LinkedIn.

Recent Questions