Can You Take Tylenol With Mucinex-D?
In our latest question and answer, the pharmacist discusses whether or not it is safe to combine Tylenol with Mucinex-D.

Question
Is it safe to take Tylenol while taking Mucinex-D?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 23, 2025
Key points
- There is no known drug interaction between Tylenol (acetaminophen) and Mucinex-D (guaifenesin; pseudoephedrine).
Answer
Yes, it is safe to combine Tylenol (acetaminophen) with Mucinex-D (guaifenesin; pseudoephedrine). There is no known interaction between them.
In fact, before pseudoephedrine and pseudoephedrine-containing products were made available only behind the pharmacy counter (due to the Combat Methamphetamine Epidemic Act), there were several products available that contained all three of these ingredients in combination together.
You can currently find several products that contain acetaminophen, guaifenesin and a similar nasal decongestant, phenylephrine, on your pharmacy shelves. An example of one such product is Tylenol Sinus Severe Daytime Pain Reliever.
There, unfortunately, is not a product that currently contains all three of the drugs in question here (guaifenesin; pseudoephedrine, acetaminophen), but as stated, it is safe to take Tylenol with Mucinex-D, which will get you all three.
About Guaifenesin
Guaifenesin is used to relieve chest congestion. Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery.
Guaifenesin is in a class of medications called expectorants and works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways.
About Acetaminophen
Acetaminophen is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever.
Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers) and works by changing the way the body senses pain and by cooling the body.
About Pseudoephedrine
Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure.
Pseudoephedrine is in a class of medications called nasal decongestants and works by causing narrowing of the blood vessels in the nasal passages.
Final Words
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References
- Pseudoephedrine Monograph, https://pubchem.ncbi.nlm.nih.gov/compound/pseudoephedrine
- Acetaminophen Monograph, https://pubchem.ncbi.nlm.nih.gov/compound/acetaminophen
- Guaifenesin Monograph, https://pubchem.ncbi.nlm.nih.gov/compound/Guaifenesin
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Dr. Brian Staiger, PharmD
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