Can You Take Tylenol With Mucinex-D?

In our latest question and answer, the pharmacist discusses whether or not it is safe to combine Tylenol with Mucinex-D.

Question

Is it safe to take Tylenol while taking Mucinex-D?

Asked by NY Philly On Oct 26, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Oct 27, 2022
Last updated Apr 13, 2024

Key points

  • There is no known drug interaction between Tylenol (acetaminophen) and Mucinex-D (guaifenesin; pseudoephedrine).

Answer

Yes, it is safe to combine Tylenol (acetaminophen) with Mucinex-D (guaifenesin; pseudoephedrine). There is no known interaction between them.

In fact, before pseudoephedrine and pseudoephedrine-containing products were made available only behind the pharmacy counter (due to the Combat Methamphetamine Epidemic Act), there were several products available that contained all three of these ingredients in combination together.

You can currently find several products that contain acetaminophen, guaifenesin and a similar nasal decongestant, phenylephrine, on your pharmacy shelves. An example of one such product is Tylenol Sinus Severe Daytime Pain Reliever.

There, unfortunately, is not a product that currently contains all three of the drugs in question here (guaifenesin; pseudoephedrine, acetaminophen), but as stated, it is safe to take Tylenol with Mucinex-D, which will get you all three.

About Guaifenesin

Guaifenesin is used to relieve chest congestion. Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery.

Guaifenesin is in a class of medications called expectorants and works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways.

About Acetaminophen

Acetaminophen is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever.

Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers) and works by changing the way the body senses pain and by cooling the body.

About Pseudoephedrine

Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure.

Pseudoephedrine is in a class of medications called nasal decongestants and works by causing narrowing of the blood vessels in the nasal passages.

Final Words

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About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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