Can You take Zoloft With Orange Juice?

Answer

Thanks for reaching out and I understand your concern! The good news here is that there is no interaction between orange juice and Zoloft (sertraline). They are safe to combine.

There are a number of potentially serious interactions between prescription drugs and some citrus juices, but orange juice is generally safe to drink with most medications.

I imagine you are thinking about the interaction between Zoloft and grapefruit juice, an interaction we wrote about just the other day.

Zoloft Interacts With Only Some Citrus Juices

As mentioned, Zoloft does interact with grapefruit (and grapefruit juice) but does not with orange juice and is safe to take with it.

Grapefruit can inhibit both the metabolizing enzyme CYP 3A4 and a transport protein known as OATP (organic anion transporting peptide). Both can affect Zoloft drug concentrations in the body. Fortunately, orange juice does not have these effects (or at least to a clinically significant degree according to most studies).

In fact, the prescribing information for Zoloft specifically mentions orange juice as safe to mix Zoloft oral solution with:

Use the dropper provided to remove the required amount of ZOLOFT oral solution and mix with 4 ounces (1/2 cup) of water, ginger ale, lemon/lime soda, lemonade or orange juice ONLY. Do not mix ZOLOFT oral solution with anything other than the liquids listed.

Talk To Your Doctor Or Pharmacist If You Are Unsure About Interactions

Thanks again for reaching out to us! This was a great question and an important one.

There are many common foods and drinks that interact with prescription drugs, so, if you are unsure if something is safe to take, be sure to ask a healthcare professional.

You, of course, can always contact us again anytime.