Can You take Zoloft With Orange Juice?

In our latest question and answer, the pharmacist discusses whether or not it is safe to take Zoloft with orange juice.


Hello, I have been taking Zoloft with orange juice for a year now without knowing that it shouldn't be taken with orange juice. What do I do now and what will happen to me? I'm very scared.

Asked by Abdul On Nov 28, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Nov 28, 2022
Last updated Nov 28, 2022

Key points

  • There is no drug interaction between Zoloft and orange juice. They can safely be combined.
  • Not all citrus is safe with Zoloft. Grapefruit, for example, has a well-documented interaction with the drug.


Thanks for reaching out and I understand your concern! The good news here is that there is no interaction between orange juice and Zoloft (sertraline). They are safe to combine.

There are a number of potentially serious interactions between prescription drugs and some citrus juices, but orange juice is generally safe to drink with most medications.

I imagine you are thinking about the interaction between Zoloft and grapefruit juice, an interaction we wrote about just the other day.

Zoloft Interacts With Only Some Citrus Juices

As mentioned, Zoloft does interact with grapefruit (and grapefruit juice) but does not with orange juice and is safe to take with it.

Grapefruit can inhibit both the metabolizing enzyme CYP 3A4 and a transport protein known as OATP (organic anion transporting peptide). Both can affect Zoloft drug concentrations in the body. Fortunately, orange juice does not have these effects (or at least to a clinically significant degree according to most studies).

In fact, the prescribing information for Zoloft specifically mentions orange juice as safe to mix Zoloft oral solution with:

Use the dropper provided to remove the required amount of ZOLOFT oral solution and mix with 4 ounces (1/2 cup) of water, ginger ale, lemon/lime soda, lemonade or orange juice ONLY. Do not mix ZOLOFT oral solution with anything other than the liquids listed.

Zoloft Prescribing Information

Talk To Your Doctor Or Pharmacist If You Are Unsure About Interactions

Thanks again for reaching out to us! This was a great question and an important one.

There are many common foods and drinks that interact with prescription drugs, so, if you are unsure if something is safe to take, be sure to ask a healthcare professional.

You, of course, can always contact us again anytime.


  • Zoloft Prescribing Information, AccessFDA
  • Perpetrators of pharmacokinetic drug-drug interactions arising from altered cytochrome P450 activity: a criteria-based assessment, PubMed
  • Fruit juices as perpetrators of drug interactions: the role of organic anion-transporting polypeptides, PubMed
  • Effect of Seville orange juice and grapefruit juice on indinavir pharmacokinetics, PubMed
  • Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4, PubMed

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Dr. Brian Staiger, PharmD

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