Can You Take Zyrtec And Pepcid Together?

Answer

There is no known drug interaction between Zyrtec (cetirizine) and Pepcid (famotidine). They are considered safe to take together.

Even though both of these drugs work by blocking histamine, they affect different histamine receptors, and can have a synergistic effect when used together.

How Does Zyrtec Work?

Zyrtec is a second-generation antihistamine, also known as an H1-blocker.

It works by binding to histamine H1-receptors. This prevents histamine from binding to these receptors, which would cause the release of a number of natural substances in the body that cause well known allergy symptoms (e.g., itching, running nose, sneezing, redness, hives etc...).

Second-generation antihistamines are, in general, longer lasting, and cause less sedation, than first-generation antihistamines (like Benadryl).

How Does Pepcid Work?

Pepcid (famotidine) is an H2-blocker. So, like Zyrtec, it blocks histamine receptors, just a different type. 

Pepcid binding to H2 receptors blocks histamine from binding, which reduces stomach acid secretion.

Combined Use Of H1 & H2-Receptor Blockers

As mentioned above, it is safe to combine Zyrtec and Pepcid.

In fact, several studies have shown that combining drugs that work on these different receptors can be very effective for certain conditions.

For example, one study concluded the following:

This study indicates that combined H1 and H2 antihistamine therapy is statistically more effective than H1 antihistamines alone in controlling the symptoms of chronic urticaria [itching].

Several other studies have found similar results.

It sounds like, in your situation, taking Zyrtec and Pepcid may work better than either drug alone to help drug the symptoms you are experiencing from your allergic reaction.

Final Words

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