Concerns With Pepto-Bismol Turning The Stool Black

In our latest question and answer, our pharmacist discusses the mechanism behind why Pepto-Bismol can turn your stool black.

Question

Is it normal for stool to appear black after taking Pepto-Bismol?

Asked by Megamark On May 28, 2024

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published May 28, 2024
Last updated Apr 25, 2025

Answer

Hello and thank you for your excellent question!

Yes, Pepto-Bismol is well known to change the color of your stool to a dark color. Although it can certainly be concerning to see your stool appear black if you aren't expecting it, it is important to know that this side effect is harmless.

Why Does Pepto-Bismol Turn Your Stool Black?

The dark color in your stool is due to bismuth sulfide, a metabolite of Pepto-Bismol after it is broken down in your system.

The mechanism behind Pepto causing a darkening of the stool is as follows:

  • Pepto-Bismol contains bismuth subsalicylate.
  • Bismuth subsalicylate breaks down in your stomach acid and releases bismuth ions (Bi³⁺) into the gastrointestinal tract.
  • These bismuth ions react with sulfur-containing compounds (hydrogen sulfide) naturally present in the intestines from dietary sources and gut bacteria activity to form an insoluble black salt, bismuth sulfide (Bi₂S₃).
  • This insoluble compound, bismuth sulfide (Bi₂S₃), is passed in your stool and causes the color of your stool to be black.

In addition to the darkening of your stool, it's not uncommon for Pepto-Bismol to cause a temporary darkening of the tongue as well.

Final Words

It is important to note that the darkening of your stool due to Pepto-Bismol use is temporary. If it persists after you have discontinued use of Pepto-Bismol, it could be an indication of other issues.

Thanks again for reaching out to us, and please do so again anytime!

References

  • Bismatrol Label Information, DailyMED
  • Bismuth Subsalicylate Monograph, PubChem

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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