Does Amoxicillin Cause Heart Palpitations Or Flutter?
In our latest question and answer, the pharmacist discusses whether or not amoxicillin causes cardiac side effects such as heart palpitations or flutter.

Question
I just finished up a 10-day course of amoxicillin for an ear infection. During those 10 days, I had heart flutters, almost a day long (FYI, I am very susceptible to PVCs, I have had various EKGs, echocardiograms, and heart monitors, Do you think that the amoxicillin caused those PVCs? I was done with my amoxicillin yesterday and today my heart is fine. Coincidence? I'm just curious as to what your thoughts are. Thank you

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 08, 2025
Key points
- Amoxicillin is not associated with cardiac side effects like some other antibiotics are (e.g. macrolides and fluoroquinolones).
Answer
While many antibiotics, such as azithromycin and levofloxacin are associated with certain types of arrhythmia, amoxicillin is not associated with cardiac side effects such as heart palpitations or flutter. In fact, the prescribing information for amoxicillin doesn't list any cardiac side effects. In addition, a history of abnormal heartbeats (e.g. PVCs) or arrhythmia is not a contraindication to amoxicillin therapy.
There is a chance your cardiac side effects were a coincidence or it could be secondary to other side effects of amoxicillin.
Although uncommon, amoxicillin therapy has been associated with certain central nervous system effects such as nervousness, anxiety, and agitation. These could make you more susceptible to cardiac problems, especially in those with a history of them.
Lastly, there is always the chance that you are experiencing rare and under-reported side effects. The FDA's Adverse Event Reporting System (FAERS) has listed over 70 cases of cardiac problems reported in 2017 alone with amoxicillin but it is important to know that there is no certainty that the reported events in the FAERS were due to the medication.
It is important to let your doctor know about the symptoms you experienced while taking amoxicillin so you can be properly evaluated.
Final Words
Thanks so much for reaching out and please do so again in the future!
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Dr. Brian Staiger, PharmD
- 10219 views