Does Plan B Cause Mood Changes?

In our latest question and answer, the pharmacist discusses whether or not Plan B can cause mood changes.

Question

I took emergency contraception (Plan B) on Monday, 2/12 after a condom failure. For the past two days, I have been experiencing some mood changes which feel like extreme PMS. I’m assuming this is due to the pill since I never have these issues. How long should I expect this to last?

Asked by Katie On Sep 13, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Sep 13, 2022
Last updated May 17, 2024

Key points

  • Plan B contains high-dose levonorgestrel. It can cause mood changes (~5-6% of individuals), but these effects should subside a few days after taking your dose.

Answer

Plan B (levonorgestrel) is an emergency contraceptive pill that contains a high dose of the progestin levonorgestrel. Like all medication, Plan B is associated with several adverse reactions, one of which is mood changes or emotional lability.

Plan B Mood Changes

Plan B contains a high dose of the progestin levonorgestrel. In fact, the dose of levonorgestrel (1.5 mg) contained in Plan B is 10 to 15 times higher than the amount contained in commonly used daily birth control pills, such as Aviane, which contains 0.1 mg of levonorgestrel.

Usual doses of daily birth control pills are known to cause mood changes in many individuals. The high dose of levonorgestrel that is contained in Plan B certainly can as well.

According to available data, high doses of levonorgestrel can cause the following effects on mood:

  • Depression or depressed mood (~ 5-6% of individuals)
  • General mood changes (~ 5% of individuals)
  • Irritability (~ 5% of individuals)

Levonorgestrel can also cause certain neurological effects, which may affect mood. These include:

  • Headache (~9-17% of individuals)
  • Migraine (~3-5% of individuals)
  • Dizziness (9% of individuals)

If any of the above side effects occur, they tend to be self-limiting and resolve in a few days. If you currently take daily hormonal birth control, the side effects may last slightly longer but should not carry over into your next cycle.

Final Words

Thanks so much for your question! Reach back out anytime.

References

  • Combined oral contraceptive use is associated with both improvement and worsening of mood in the different phases of the treatment cycle-A double-blind, placebo-controlled randomized trial, PubMed
  • Oral contraceptive use changes brain activity and mood in women with previous negative affect on the pill--a double-blinded, placebo-controlled randomized trial of a levonorgestrel-containing combined oral contraceptive, PubMed

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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