Does Plan B Cause Mood Changes?
In our latest question and answer, the pharmacist discusses whether or not Plan B can cause mood changes.

Question
I took emergency contraception (Plan B) on Monday, 2/12 after a condom failure. For the past two days, I have been experiencing some mood changes which feel like extreme PMS. I’m assuming this is due to the pill since I never have these issues. How long should I expect this to last?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 18, 2025
Key points
- Plan B contains high-dose levonorgestrel. It can cause mood changes (~5-6% of individuals), but these effects should subside a few days after taking your dose.
Answer
Plan B (levonorgestrel) is an emergency contraceptive pill that contains a high dose of the progestin levonorgestrel. Like all medication, Plan B is associated with several adverse reactions, one of which is mood changes or emotional lability.
Plan B Mood Changes
Plan B contains a high dose of the progestin levonorgestrel. In fact, the dose of levonorgestrel (1.5 mg) contained in Plan B is 10 to 15 times higher than the amount contained in commonly used daily birth control pills, such as Aviane, which contains 0.1 mg of levonorgestrel.
Usual doses of daily birth control pills are known to cause mood changes in many individuals. The high dose of levonorgestrel that is contained in Plan B certainly can as well.
According to available data, high doses of levonorgestrel can cause the following effects on mood:
- Depression or depressed mood (~ 5-6% of individuals)
- General mood changes (~ 5% of individuals)
- Irritability (~ 5% of individuals)
Levonorgestrel can also cause certain neurological effects, which may affect mood. These include:
- Headache (~9-17% of individuals)
- Migraine (~3-5% of individuals)
- Dizziness (9% of individuals)
If any of the above side effects occur, they tend to be self-limiting and resolve in a few days. If you currently take daily hormonal birth control, the side effects may last slightly longer but should not carry over into your next cycle.
Final Words
Thanks so much for your question! Reach back out anytime.
References
- Combined oral contraceptive use is associated with both improvement and worsening of mood in the different phases of the treatment cycle-A double-blind, placebo-controlled randomized trial, PubMed
- Oral contraceptive use changes brain activity and mood in women with previous negative affect on the pill--a double-blinded, placebo-controlled randomized trial of a levonorgestrel-containing combined oral contraceptive, PubMed
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Dr. Brian Staiger, PharmD
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