Does Amoxicillin Suspension Contain Sugar?

In our latest question and answer, the pharmacist discusses how much sugar is contained in amoxicillin suspension.

Question

Is amoxicillin 400mg per 5 ml size 75 ml bottle solution sugar-free? Can diabetics take it? The specific drug I am asking about is Aurobindo amoxicillin - NDC 65862-071-75.

Asked by Ami On Oct 18, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Oct 18, 2022
Last updated May 02, 2024

Key points

  • Amoxicillin suspension does contain sugar (listed as sucrose in the product labeling), but the amount varies by specific product and manufacturer.
  • Most amoxicillin suspension products contain around 2-3 grams of sugar per 5mL (one teaspoon).

Answer

Yes, amoxicillin suspension does contain sugar (listed as sucrose in the product labeling).

The specific product you state in your question (amoxicillin 400mg/5mL manufactured by Aurobindo - NDC 65862-071-75) lists 'sucrose' as an inactive ingredient in the prescribing information for the drug:

Each 5 mL of reconstituted suspension contains amoxicillin trihydrate equivalent to 200 mg or 400 mg anhydrous amoxicillin. Each 5 mL of the 200 mg and 400 mg reconstituted suspension contains 0.16 mEq (3.61 mg) of sodium; Inactive ingredients: sucrose, sodium citrate, sodium benzoate, edetate disodium, FD&C Red No. 3, xanthan gum, bubble-gum flavor, and colloidal silicon dioxide.
DailyMED Amoxicillin Suspension Product Labeling

How Much Sugar Does Amoxicillin Suspension Contain?

Most amoxicillin suspension products do not list the exact amount of sugar contained in them as sugar is an inactive ingredient, and the precise amount is not required to be labeled.

Nevertheless, studies of sweeteners in pediatric liquid medications show that the sucrose content can range from 18%-80% (this would equate to between 0.9 grams to 4 grams of sugar per 5mL of liquid), depending on the product. Per one study:

Sweetener information on 160 preparations was obtained. For antibiotics such as ampicillin, amoxicillin, erythromycin ethylsuccinate, and penicillin VK, products from different manufacturers had a wide range of sucrose concentration (18%-80%).
American Journal of Hospital Pharmacy, Volume 45, Issue 1, 1 January 1988, Pages 135–142,

Comparable prescription antibiotic suspension products that are available in Canada and the UK contain between 2 and 3 grams of sucrose (i.e., sugar) per teaspoonful (5mL). This equates to 40%-60% sucrose concentration, so right in line with the above study results.

Although the exact amount of sugar in the product you mention (Aurobindo amoxicillin 400mg/5mL) isn't labeled, it's expected to contain around 2-3 grams per teaspoon (5mL). Please note that I have reached out to Aurobindo for this exact information and will provide it when it is available.

Can A Diabetic Safely Use Amoxicillin Suspension Since It Contains Sugar?

If you are diabetic, you certainly want to be aware of your sugar and overall carbohydrate intake. This is especially true if you inject a certain amount of insulin based on how many carbohydrates you ingest.

As mentioned in the section above, amoxicillin suspension products do contain sugar, but it is a relatively low amount, around 2 to 3 grams per 5mL (which equates to 8 to 12 calories per 5mL).

Overall, amoxicillin suspension is safe for diabetics based on the low sugar content but be aware and take into account the fact that it does contain some and adjust your diet/insulin therapy as appropriate.

Final Words

Thanks for reaching out and I hope this answer was helpful!

References

  • Amoxicillin 125mg/5ml Oral Suspension BP, Kent Pharma UK Ltd
  • Sweetener content of common pediatric oral liquid medications, PubMed
  • Amoxicillin by Sanis, Med Broadcast
  • Sweetener content and cariogenic potential of pediatric oral medications: A literature, PubMed

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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