Does Benadryl Make Your Heart Race?
In our latest question and answer, the pharmacist discusses whether or not Benadryl, an over-the-counter antihistamine, can cause your heart to race.
Question
I took Benadryl and feel like it has opposite effects on me. My heart pounds. Does Benadryl make your heart race?
Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 25, 2024
Key points
- Benadryl has been documented to cause an increased heart rate in some individuals.
- An increased heart rate from Benadryl is most commonly seen in children and in cases of an overdose.
- Certain individuals may have a genetic variation that increases concentrations of a Benadryl metabolite that causes excitation.
Answer
Yes, Benadryl can increase your heart rate (i.e. "make your heart race"), even at recommended doses. This is because Benadryl, a sedating "first-generation" antihistamine, has strong anticholinergic effects.
Common anticholinergic side effects include:
- Feeling hot or overheated
- Constipation
- Dry eyes
- Dry mouth
- Tachycardia (i.e. increased heart rate)
- Confusion
- Sedation
- Dry skin
- Flushing
It should be noted that cardiac side effects of Benadryl, such as increased heart rate, aren't all that common. Nevertheless, if your heart rate has increased after dosing with Benadryl, or you are having palpitations, it may be the culprit.
Benadryl Causing Excitation
In addition, Benadryl has been reported to rarely cause "paradoxical excitation" in some individuals. It appears to be more common in children as well as in cases of an overdose according to the prescribing information for the drug. Symptoms of this include:
- Restlessness
- Agitation
- Insomnia
- Muscle spasms
- Increased heart rate
The side effect of "excitation" is noted as paradoxical as Benadryl is more commonly associated with a feeling of sedation, which is why it is used as a sleep aid.
Lastly, it appears certain individuals are more susceptible to the "excitation" side effects of Benadryl than others. The theory is that some individuals have genetic variations that increase the metabolism of Benadryl, increasing concentrations of an excitatory metabolite.
Final Words
Thanks again for your question!
- Dr. Brian Staiger, PharmD
- 13640 views