Does Genistein Interact With Abiraterone?
In our latest question and answer, the pharmacist discusses the use of genistein with abiraterone.
Is it safe to take Genistein with abiraterone?
Last updated Aug 11, 2023
- While there is no direct evidence of an interaction between genistein and abiraterone, studies on the matter are lacking and more information is needed to make a definitive determination in this regard.
There is limited information available on the potential interaction between genistein and abiraterone. While there is no direct evidence of a drug interaction, it is always recommended to consult with your doctor before taking any new supplements or making changes to your medication regimen.
They can provide personalized advice based on your specific health condition and medications and can monitor you accordingly when changes to your medication regimen are made.
Genistein is a naturally occurring compound found in soybeans and other legumes. It is classified as a phytoestrogen due to its structural similarity to estrogen.
Genistein has been studied for its potential health benefits, particularly in relation to hormone-related conditions such as menopausal symptoms and certain types of cancers.
When it comes to drug interactions, the available information on genistein is limited, and specific interactions with abiraterone have not been well studied (I personally could not find any studies where the two were referenced together).
Some evidence suggests that genistein may interact with caffeine and may affect the activity of the liver enzyme CYP2C9, which is involved in the metabolism of many drugs. It is important to note that most of these findings are based on animal studies, and more research is needed to understand the potential interactions in humans.
Abiraterone, a medication used to treat certain types of cancer, works by inhibiting an enzyme called CYP17, which is involved in the production of testosterone.
It is primarily metabolized by the liver, primarily through the CYP2D6 enzyme pathway.
Genistein is not known to affect this enzyme (CYP2D6) but given the limited available information on genistein and the lack of specific studies on its interaction with abiraterone, it is difficult to definitively determine whether there would be any significant interactions between the two.
In summary, there is currently limited information on the potential interaction between genistein and abiraterone. Genistein has not been extensively studied for drug interactions, and specific studies on its interaction with abiraterone are lacking.
It is always recommended to consult with your doctor before taking any new supplements or making changes to your medication regimen as they know your medical situation best and can monitor you accordingly.
Thanks for reaching out!
- Dr. Brian Staiger, PharmD
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