Horsetail Drug Interaction Question

In our latest question and answer, the pharmacist discusses whether or not the herbal 'horsetail' interacts with several different prescription medications.

3 min read Updated Jun 2026 3,154 views
Horsetail Drug Interaction Question
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Melissa asked

Is it ok if I take a Horsetail herb with my regular medications? They are: Atorvastatin 10mg, Baclofen 20mg, Lisinopril 20mg, Ibuprofen 800 mg, Multivitamins and an iron tablet 65mg.

Dec 23, 2022
The quick answer
  • Horsetail is not known to interact with Lipitor, Baclofen, Lisinopril, Ibuprofen, or multivitamins.
  • Horsetail may interact with diuretics, antidiabetic drugs, and antivirals because it can have diuretic effects and may lower blood sugar levels.
  • Some species of horsetail contain thiaminase which can cause thiamine deficiency with prolonged use, and certain species may be toxic and should not be consumed.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.

Answer

Thanks so much for reaching out! I'm always more than happy to help with drug-herbal interaction questions. Horsetail, of which there are several species (e.g., Equisetum arvense), is not known to interact with the drugs you mentioned in your question, which are:

  • Lipitor (atorvastatin)
  • Baclofen
  • Lisinopril
  • Ibuprofen
  • Multivitamins

I always like to give the caveat that it can be incredibly difficult to definitively know what drugs could potentially interact with a particular herbal medication simply due to the lack of information available. Therefore, it is important to talk to your doctor before combining the drugs you take with anything available over the counter.

Having said that, based on what is known about the effects of horsetail, we wouldn't expect an interaction with your drugs.

What Does Horsetail Interact With?

Horsetail may interact with several different classes of drugs, including:

  • Diuretics
  • Antidiabetics
  • Antivirals

Horsetail is thought to have diuretic properties as some studies have shown it can even produce a diuretic effect on par with a prescription medication known as hydrochlorothiazide, at least in the short term. Therefore, combining it with other diuretics could cause additive effects.

Same with drugs that lower blood sugar. Horsetail has been linked with improving blood sugar levels, so taking it with drugs for diabetes could potentially drop sugar too low.

Lastly, there have been case reports of horsetail reducing the effectiveness of some antivirals commonly used to treat HIV.

This isn't intended to be a complete list of horsetail interactions, so please be sure to talk to your doctor before making any changes to your medication regimen. You can also always contact us regarding specific drug-herbal interaction questions.

What Is Horsetail?

Horsetail, also known as equisetum, is a type of perennial herb that belongs to the Equisetaceae family. It is native to much of the Northern Hemisphere and has distinctive, jointed stems that resemble the tail of a horse, hence the common name.

Some species of horsetail are used medicinally and have been traditionally used to treat a range of ailments, including kidney and bladder problems, wounds, and hair loss.

It is most commonly used in traditional medicine as an oral diuretic (i.e., water pill) for the treatment of edema.

It is important to note that some species of horsetail (e.g., Equisetum palustre) may be toxic and should not be consumed. Additionally, some types of horsetail contain thiaminase, which can cause thiamine deficiency with prolonged use.

Final Words

Thanks again for using us. We are working on a 'drug-herbal' interaction checker for this website soon, so please continue to check back!

Contact us again anytime!

References & sources
  1. Possible Drug-Herb Interaction between Herbal Supplement Containing Horsetail ( Equisetum arvense) and Antiretroviral Drugs — PubMed
  2. Hypoglycemic effect of Equisetum myriochaetum aerial parts on type 2 diabetic patients — PubMed
  3. Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum arvense (Field Horsetail) in Healthy Volunteers — PubMed
Glossary — Terms in This Answer
Diuretic
A medication or substance that increases urine production and helps remove excess water from the body.
Antidiabetics
Medications used to lower blood sugar levels in people with diabetes.
Antivirals
Drugs designed to fight viral infections by stopping viruses from multiplying in the body.
Additive effects
When two substances combine to produce a stronger overall effect than either would have alone.
Edema
Swelling caused by excess fluid buildup in body tissues.
Thiaminase
An enzyme that breaks down thiamine (vitamin B1) in the body.
Thiamine deficiency
A condition caused by inadequate levels of vitamin B1, which can lead to nerve damage and other health problems.
Perennial herb
A plant that lives for more than two years and regrows naturally each season.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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