Is Elderberry Safe To Take With Lisinopril?

In our latest question and answer, the pharmacist discusses whether or not lisinopril is safe to take with elderberry supplements.

2 min read Updated Jun 2026 Read by 2,844 people
Is Elderberry Safe To Take With Lisinopril?
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Lia asked

I'm wondering if it is safe to combine my blood pressure medicine lisinopril with elderberry.

Jul 07, 2022
The quick answer
  • Elderberry and lisinopril are safe to take together with no known interactions between them. Elderberry is not known to affect blood pressure, making it safe for use alongside your blood pressure medication.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.
Medications in this answer — tap to explore

Hello and thanks for reaching out to us! It's always a good idea to check into potential interactions with prescription drugs, and we're here to help!

Based on published studies evaluating elderberry and what we know about lisinopril, there are no known or expected interactions between the drugs. They are considered safe to take together.

Elderberry also is not known to affect blood pressure, so it appears safe in that regard as well. So, if you have cold or flu symptoms, and you want to take a supplement that contains elderberry, available evidence suggests there is no problem doing that.

What Is Elderberry?

Elderberry has a long history of use medically for its purported immune system-enhancing effects. It is mostly marketed in over-the-counter supplements to help shorten the duration of colds and the flu.

Although there have been relatively few studies testing how well it works in this regard, some small clinical studies have shown it can affect different components of the immune system (e.g. cytokines) and may have positive benefits in healthy adults and children. Other studies have shown no benefit, however. More rigorous studies are needed to better understand exactly the benefits it can have as a supplement.

Regardless, elderberry seems relatively safe to use in amounts that would commonly be found in food. In fact, it is 'generally recognized as safe' (GRAS) by the FDA.

There are no known drug interactions between elderberry and prescription or over-the-counter medications.

Based on studies showing that it may have immunostimulating effects, it theoretically could interact with immunosuppressants, but this has not been shown clinically. Regardless, simply due to the lack of available information, it should not be combined with drugs that work by suppressing the immune system.

What Is Lisinopril?

Lisinopril is used alone or in combination with other medications to treat high blood pressure in adults and children 6 years of age and older. It is used in combination with other medications to treat heart failure.

Lisinopril is also used to improve survival after a heart attack. Lisinopril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors and works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump blood more efficiently.

Final Words

Thanks again for reaching out to us!

References & sources
  1. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines — PubMed
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe — AccessFDA
  3. Lisinopril Monograph — PubChem
Glossary — Terms in This Answer
Lisinopril
A prescription medication that lowers blood pressure and helps the heart work more efficiently by relaxing blood vessels.
ACE inhibitors
A class of blood pressure medications that work by relaxing blood vessels to allow blood to flow more easily.
Immunostimulating
Having the ability to boost or activate the body's immune system.
Immunosuppressants
Medications that reduce or suppress the activity of the immune system.
Cytokines
Proteins produced by immune cells that help coordinate immune system responses.
GRAS
A FDA designation meaning a substance is 'Generally Recognized As Safe' for food use.
Drug interactions
When two medications affect each other's effectiveness or safety when taken together.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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