Is Elderberry Safe To Take With Lisinopril?

In our latest question and answer, the pharmacist discusses whether or not lisinopril is safe to take with elderberry supplements.

Question

I'm wondering if it is safe to combine my blood pressure medicine lisinopril with elderberry.

Asked by Lia On Jul 07, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Jul 07, 2022
Last updated Apr 10, 2025

Key points

  • There is no known drug interaction between elderberry and lisinopril.

Hello and thanks for reaching out to us! It's always a good idea to check into potential interactions with prescription drugs, and we're here to help!

Based on published studies evaluating elderberry and what we know about lisinopril, there are no known or expected interactions between the drugs. They are considered safe to take together.

Elderberry also is not known to affect blood pressure, so it appears safe in that regard as well. So, if you have cold or flu symptoms, and you want to take a supplement that contains elderberry, available evidence suggests there is no problem doing that.

What Is Elderberry?

Elderberry has a long history of use medically for its purported immune system-enhancing effects. It is mostly marketed in over-the-counter supplements to help shorten the duration of colds and the flu.

Although there have been relatively few studies testing how well it works in this regard, some small clinical studies have shown it can affect different components of the immune system (e.g. cytokines) and may have positive benefits in healthy adults and children. Other studies have shown no benefit, however. More rigorous studies are needed to better understand exactly the benefits it can have as a supplement.

Regardless, elderberry seems relatively safe to use in amounts that would commonly be found in food. In fact, it is 'generally recognized as safe' (GRAS) by the FDA.

There are no known drug interactions between elderberry and prescription or over-the-counter medications.

Based on studies showing that it may have immunostimulating effects, it theoretically could interact with immunosuppressants, but this has not been shown clinically. Regardless, simply due to the lack of available information, it should not be combined with drugs that work by suppressing the immune system.

What Is Lisinopril?

Lisinopril is used alone or in combination with other medications to treat high blood pressure in adults and children 6 years of age and older. It is used in combination with other medications to treat heart failure.

Lisinopril is also used to improve survival after a heart attack. Lisinopril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors and works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump blood more efficiently.

Final Words

Thanks again for reaching out to us!

References

  • The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines, PubMed
  • Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe, AccessFDA
  • Lisinopril Monograph, PubChem

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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