Is It Safe To Use Amoxicillin And Hyland's Kids Cold & Cough Together?

In our latest question and answer, the pharmacist discusses whether or not there is a drug interaction between amoxicillin and Hyland's cough syrup.

2 min read Updated Jun 2026 Read by 10,893 people
Is It Safe To Use Amoxicillin And Hyland's Kids Cold & Cough Together?
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Jon asked

Is it safe to give Hyland's Kids Cough & Cold with amoxicillin?

Dec 28, 2022
The quick answer
  • There is no known drug interaction between Hyland's Kids Cold & Cough and amoxicillin, and they are safe to take together.
  • Hyland's Kids Cold & Cough is a homeopathic product that contains highly diluted ingredients with very small amounts of active components, which means it does not pose a risk of interacting with amoxicillin.
  • You can use both products together to help treat a bacterial infection while providing symptom relief for cold and cough symptoms.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.
Medications in this answer — tap to explore

Answer

Thanks so much for reaching out! We love answering questions like this so please feel free to always reach out when something like this comes up for you.

Getting into your question, there is no known drug interaction between Hyland's Kids Cough & Cold and amoxicillin. They are considered safe to take together.

Hyland's Kids Cold & Cough is a homeopathic product, and homeopathic products generally don't have a risk of drug interactions due to the very small amounts of active ingredients used in them (although this isn't always the case as some homeopathic products (e.g., Cold-Eeze) do contain enough active ingredients to interact with some drugs).

What Is In Hyland's 4Kids Cold & Cough?

Hylands Cough and Cold Kids Bottle With Drug Facts

The specific ingredients contained in Hyland's 4Kids Cold & Cough are:

  • Allium Cepa 6X 
  • Hepar Sulph Calc 12X
  • Hydrastis 6X
  • Natrum Muriaticum 6X
  • Phosphorus 12X
  • Pulsatilla 6X 
  • Sulphur 12X

Homeopathic products are based on the principle of 'like cures like". They contain ingredients that are highly diluted, which in larger amounts, would cause the symptoms that are being treated.

For example, in homeopathy, a runny nose would be treated with a very small amount of something that would normally cause a runny nose, like an onion. Hyland's 4Kids Cold & Cough contains Allium Cepa, which is an extract obtained from onions.

All of the ingredients in Hyland's 4Kids Cold & Cough are homeopathic and highly diluted. There is nothing in it that is known to interact with amoxicillin. You can feel safe combining them.

Final Words

I imagine you asked your question because your child is sick and, in addition to using amoxicillin to treat a bacterial infection, you are looking to provide additional symptom relief. As mentioned, Hyland's 4Kids Cold & Cough is safe to use, and I hope it helps your child feel better.

Thanks again for reaching out!

References & sources
  1. Amoxicillin Monograph — PubChem
  2. Hyland's Naturals Kids Cold & Cough — Hylands
  3. Systematic Review of Plant-Based Homeopathic Basic Research: An Update — PubMed
Glossary — Terms in This Answer
Drug interaction
A change in how a medication works when taken together with another drug or substance.
Homeopathic
A system of medicine based on using highly diluted natural substances to treat symptoms.
Active ingredients
The components in a medication or product that produce the intended therapeutic effect.
Amoxicillin
An antibiotic medication used to treat bacterial infections.
Diluted
Made weaker or less concentrated by adding another substance, typically water.
Extract
A concentrated substance obtained by removing the desired component from a plant or material.
Bacterial infection
An illness caused by harmful bacteria growing in the body.
Symptom relief
Treatment that reduces or lessens the uncomfortable signs of illness.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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