Is Pepcid Safe To Take With Metronidazole?

In our latest question and answer, the pharmacist discusses whether or not there is an interaction between metronidazole and Pepcid (famotidine).

Question

Is there an interaction between famotidine and metronidazole?

Asked by zee On Feb 01, 2025

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Feb 01, 2025
Last updated Apr 10, 2025

Answer

Thank you for your question regarding the potential interaction between famotidine and metronidazole! We appreciate you contacting us.

Famotidine, the generic name for Pepcid (and Pepcid AC, a popular over-the-counter drug), is an H2 receptor blocker that works by reducing stomach acid production.

It's always wise to check for potential interactions when considering new medications, and famotidine is no exception. Because it reduces stomach acid, famotidine can alter the pH of the stomach, and this change may sometimes affect the absorption of certain medications.

For example, drugs such as ketoconazole and itraconazole require an acidic environment for optimal absorption, and their effectiveness may be reduced when taken alongside acid-reducing agents like famotidine.

In the case of metronidazole, however, there is no evidence to suggest a clinically significant interaction with famotidine. Metronidazole's absorption and overall efficacy are not notably affected by changes in gastric pH, making the concurrent use of these medications generally safe.

Final Words

If you have any further questions or concerns about your medications, please consult your healthcare provider for personalized advice. Thank you again for reaching out!

References

  • Flagyl Prescribing Information, Pfizer
  • Prediction of gastric pH‐mediated drug exposure using physiologically‐based pharmacokinetic modeling: A case study of itraconazole, PubMed

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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