Is There An Interaction Between Bergamot And Zetia?

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I have not found any evidence of a drug interaction between Zetia (ezetimibe), a medication used to lower cholesterol, and bergamot, a citrus fruit whose extract is often used as a dietary supplement for its supposed cardiovascular benefits.

Additionally, our Drug-Herbal Interaction Checker does not indicate any interaction between bergamot and Zetia. You can find more information about bergamot interactions on our website.

Additional Details

Zetia is not known to have many drug interactions due to how it's metabolized in our body. While it does have some interactions, it is generally considered safe to take with most other medications (we have a list of ezetimibe interactions that can be found here).

Similarly, bergamot is not known to have many interactions either. It is not known to affect any CYP metabolizing enzymes, which is a major mechanism behind most drug interactions.

Based on the current information available, bergamot mainly interacts with two types of drugs: antidiabetic drugs and photosensitizing drugs, and these are considered to be very minor in most cases.

Regarding antidiabetic drugs, bergamot may lower blood glucose levels, potentially enhancing the effects of other drugs that do the same. You can see an example of an interaction detail page between bergamot and metformin on our website.

Regarding photosensitizing drugs, topical bergamot essential oil might theoretically increase the risk of side effects when used with photosensitizing drugs due to its bergapten content, which has photosensitizing effects. An example of this interaction is between bergamot and doxycycline.

Final Words

To sum up, based on what we know about how bergamot and Zetia work and are metabolized, we wouldn't expect an interaction between them.