Is Tylenol Safe To Take With Entocort (Budesonide)?
In our latest question and answer, our pharmacist discusses whether or not there is an interaction between Entocort and acetaminophen.

Question
Can you take Entocort EC and Tylenol Arthritis medications together?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 10, 2025
Key points
- There is no known drug interaction between Tylenol Arthritis and Entocort EC.
Answer
Hi Zoe and thanks for reaching out!
There is no known drug interaction between Entocort (budesonide) and Tylenol Arthritis (acetaminophen extended-release). They are safe to take together.
Assuming for are taking Entocort for Crohn's disease, Tylenol (acetaminophen) is generally a safer choice than other pain relievers, like ibuprofen or naproxen, as it has fewer gastrointestinal side effects.
About Entocort
Entocort EC (budesonide) is used to treat Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever).
Entocort EC is in a class of medications called corticosteroids. It works by decreasing inflammation (swelling) in the digestive tract of people who have Crohn's disease or in the kidney of people with nephropathy.
About Tylenol
Tylenol (acetaminophen) is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever. acetaminophen may also be used to relieve the pain of osteoarthritis (arthritis caused by the breakdown of the lining of the joints).
Tylenol (acetaminophen) is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body. Tylenol Arthritis is an extended-release form of acetaminophen.
Final Words
Thanks again for your question and please feel free to reach out again in the future!
References
- Budesonide Monograph, PubChem
- Acetaminophen Monograph, PubChem
- Entocort EC Prescribing Information, AcccessFDA
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Dr. Brian Staiger, PharmD
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