Is Tylenol Safe To Take With Prednisone?

In our latest question and answer, the pharmacist discusses whether or not Tylenol is safe to take with prednisone.


Hello, I am wondering if it is okay to take Tylenol and prednisone together. Thank you

Asked by Daphne On Jul 16, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Jul 16, 2022
Last updated Jul 16, 2022

Key points

  • There is no known interaction between Tylenol (acetaminophen) and prednisone, they are considered safe to take together.


Hello and thanks for reaching out! I'm more than happy to answer this for you.

Tylenol (acetaminophen) is considered safe to take with prednisone. There are no known interactions between the drugs.

In fact, Tylenol is the OTC (over-the-counter) pain reliever of choice to take with prednisone for most individuals as ibuprofen has a moderate interaction with it, and needs to be taken cautiously.

About Tylenol

Acetaminophen is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever. It may also be used to relieve the pain of osteoarthritis (arthritis caused by the breakdown of the lining of the joints).

Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body.

About Prednisone 

Prednisone is used alone or with other medications to treat the symptoms of low corticosteroid levels (lack of certain substances that are usually produced by the body and are needed for normal body functioning). It is also used to treat other conditions in patients with normal corticosteroid levels. These conditions include certain types of arthritis; severe allergic reactions; multiple sclerosis (a disease in which the nerves do not function properly); lupus (a disease in which the body attacks many of its own organs); and certain conditions that affect the lungs, skin, eyes, kidneys blood, thyroid, stomach, and intestines.

Prednisone is also sometimes used to treat the symptoms of certain types of cancer.

Prednisone is in a class of medications called corticosteroids. It works to treat patients with low levels of corticosteroids by replacing steroids that are normally produced naturally by the body. It works to treat other conditions by reducing swelling and redness and by changing the way the immune system works.

Final Words

Thanks again for your question!


About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at! You can also connect with Dr. Brian Staiger on LinkedIn.

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