Is Voltaren Gel Absorbed Systemically?

In our latest question and answer, our pharmacist discusses whether or not topical Voltaren gel is absorbed systemically (into your bloodstream).


Hi, I'm taking Voltaren gel OTC and I've been told it is an NSAID. Since I'm applying this to my skin, does it actually get absorbed into my bloodstream like it would if I took it by mouth?

Asked by George R. On Sep 01, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Sep 01, 2022
Last updated Sep 01, 2022

Key points

  • Voltaren Gel (Diclofenac 1%) is absorbed systemically, but very minimally when compared to oral diclofenac.
  • Applying 16 grams of Voltaren Gel 1% (equating to 160 mg of diclofenac) results in only about 6% total systemic exposure when compared to 150 mg of oral diclofenac tablets.
  • Studies have reported that gastrointestinal side effects (among the most common side effects occurring with oral NSAIDs) with Voltaren Gel occur at rates as placebo.
  • Unless directed by your doctor, it is generally not recommended to use Voltaren Gel long-term with other oral NSAIDs due to the lack of safety studies.


Voltaren gel contains diclofenac, an NSAID (non-steroidal anti-inflammatory drug), and is used (primarily) to treat osteoarthritis. Your question is fairly common among individuals who are prescribed Voltaren gel regarding is whether or not it is absorbed systemically (i.e. into the bloodstream) after it is applied.

Systemic absorption of diclofenac is of significant concern when talking about things like potential side effects and drug interactions.

Regarding side effects specifically, many studies report that diclofenac has a higher risk of gastrointestinal and liver toxicity when compared to other oral NSAIDs.

Therefore, knowing just how much of the drug is absorbed when you apply it is important to consider.

What Is Diclofenac?

Diclofenac Chemical StructureDiclofenac is a nonsteroidal anti-inflammatory drug (NSAID), belonging specifically to the acetic acid chemical class of NSAIDs. NSAIDs, in general, are used for their anti-inflammatory, analgesic (i.e. pain-relieving), and antipyretic (i.e. fever-reducing) properties.

Diclofenac is one of the most versatile NSAIDs when it comes to how it is utilized in prescription drugs. It is available in a multitude of products and dosage forms, including:

  • Cataflam (diclofenac potassium oral tablets)
  • Voltaren (diclofenac sodium oral tablets)
  • Voltaren Gel
  • Flector Patches
  • Zorvolex (capsules)
  • Zipsor (liquid capsules)
  • Cambia (powder)
  • Voltaren Ophthalmic (eye drops)
  • Voltaren XR (extended-release tablets)
  • Dyloject
  • Solaraze (Topical gel 3%)
  • Pennsaid (Topical Solution)

Of the oral products, you may notice that is available as both diclofenac sodium and diclofenac potassium, different salt forms of the same drug.

Potassium salts of diclofenac (e.g. Cataflam) are absorbed more quickly and produce higher plasma concentrations, which is generally why they have a faster onset of action than other oral forms of diclofenac. The sodium salt of diclofenac (e.g. Voltaren tablets) has a slower onset of action compared to diclofenac potassium.

As a general point, oral diclofenac products aren't prescribed as often as other NSAIDs, since studies show that it is likely to cause higher rates of liver and GI toxicity than most other NSAIDs.

How Much Diclofenac Is In Voltaren Gel?

Question Mark Wood Blocks Stock Image

It is extremely important to point out, and remember, that Voltaren gel is supplied at a strength of 1% (meaning 1000 mg of diclofenac per 100 grams of gel).

Even though the total amount of Voltaren gel applied seems quite large (generally between 16 and 48 grams per day), the amount of actual diclofenac you are applying is relatively low.

For example:

  • If you are applying one gram of Voltaren gel, that equates to 10 mg of diclofenac.
  • If you are applying 16 grams of Voltaren gel per day, that equates to 160 mg of diclofenac.
  • If you are applying 48 grams of Voltaren gel per day, that equates to 480 mg of diclofenac.

Voltaren Gel Absorption

Gel Pile Stock Image

This article deals specifically with Voltaren Gel absorption.

All of the other topical dosage forms (e.g. Flector patches, Pennsaid solution) have different absorption characteristics so be sure not to extrapolate data on Voltaren Gel to those other products.

If you have questions about any other product that contains diclofenac, be sure to ask one of our pharmacists.

At the outset, the good news is that multiple studies report that topical NSAIDs, like Voltaren Gel, work as well as oral forms for the treatment of a variety of conditions, including:

  • Osteoarthritis
  • Acute musculoskeletal pain

Additionally, most studies find no difference in topical NSAIDs from placebo in reported systemic side effects like stomach upset and gastrointestinal bleeding.

One of the largest review studies on topical NSAIDs states the following:

Topical NSAIDs penetrate the skin, enter tissues or joints, and reduce processes causing pain in the tissue. Drug levels in the blood with topical NSAIDs are very much lower than with the same drug taken by mouth. This minimises the risk of harmful effects.
Cochrane Database Syst Rev. 2015 Jun; 2015(6): CD007402.

How Much Diclofenac Is Absorbed After Applying Voltaren?

In terms of how much Voltaren gel is absorbed systemically, the prescribing information says the following:

Systemic exposure (area under the concentration-time curve) and maximum plasma concentrations of diclofenac are significantly lower with Voltaren® Gel than with comparable oral treatment of diclofenac sodium.
Voltaren Gel Prescribing Information

While 'significantly lower' is somewhat vague, fortunately, the prescribing information gives more detailed information on the total systemic absorption of the drug after applying topically.

The following is reported based on pharmacokinetic studies of the drug:

  • Systemic exposure with Voltaren Gel (4 x 4 g per day) is, on average, 17 times lower than with oral treatment (i.e. only 6%) of diclofenac sodium.
  • Systemic exposure with Voltaren Gel (4 x 12 g per day) is, on average, 5 times lower than with oral treatment (i.e. only 20%) of diclofenac sodium.
  • The average peak plasma concentration with the recommended use of Voltaren® Gel (4 x 4 g per day applied to 1 knee) is 158 times lower than with the oral treatment.

The following is a data chart straight from the prescribing information for Voltaren gel quantifying these characteristics.

Voltaren Gel Systemic Absorption Compared To Oral Chart From Prescribing Information

This comparison information for topical Voltaren gel and oral diclofenac from the figure above is summarized in the below chart:

Chart - Exposure From Topical And Oral Diclofenac

Drug Maximum Systemic Concentration (ng/mL) Avg % Concentration Compared To Oral Diclofenac (150 mg per day) % AUC (i.e. Total systemic exposure) Compared To Oral Diclofenac (150 mg per day)
Voltaren Gel (16 grams gel per day = 160mg diclofenac) 15 ± 7.3 0.6% 5.8%
Voltaren Gel (48 grams gel per day = 480 mg diclofenac) 53.8 ± 32 2.2% 19.7%
Diclofenac Sodium Oral Tablets (150 mg) 2270 ± 778 100% 100%

To clarify why 16 grams of Voltaren gel contains 160 mg of diclofenac, remember that in one of the sections above (How Much Diclofenac Is In Voltaren Gel?), we pointed out that Voltaren gel is available in a 1% strength, meaning that it contains 1 gram of diclofenac (1,000 mg) per 100 grams of gel.

This is why 16 grams of Voltaren gel contains only 160mg of diclofenac (16 grams * 1% = 0.16 grams, or 160 mg).

So, overall, you can see that both maximum concentrations in the plasma and total systemic absorption of Voltaren gel are extremely low when compared to oral diclofenac.

Even if you are applying a very high dose of Voltaren gel (48 grams per day), maximum concentrations and total systemic exposure are, respectively, only 2.2% and 19.7% when compared to taking 150 mg of oral diclofenac.

However, and this is important to note, there aren’t any studies that have charted the correlation between plasma concentrations and the risk of side effects or drug interactions. While it certainly makes sense that the risk of side effects and interactions would be significantly lower with topical Voltaren gel, you can’t rule out them occurring.

Can You Use Oral NSAIDs With Voltaren Gel?

Pile Of Pills Stock

In most cases, it is not recommended to use both a topical and oral NSAID together. Studies show that combining them doesn't seem to work better than either alone and may increase the risk of side effects.

Additionally, the clinical trials of Voltaren Gel (as referenced in the prescribing information for the drug) prohibited the concomitant use of oral NSAIDs, so we don't know how patients would have responded to both.

As discussed in this article, there at least is some systemic exposure to diclofenac following normal use of Voltaren Gel, and therefore, there may be an increased risk of side effects if used with oral NSAIDs.

So overall, due to the lack of safety data (and the fact that preliminary studies suggest that the combo isn't effective), you shouldn't combine an oral and topical NSAID unless otherwise directed by your doctor.

Final Words

Thanks so much for your question and I hope this answer helped. Please feel free to reach back out in the future!


  • A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly, PubMed
  • Diclofenac: an update on its mechanism of action and safety profile, PubMed
  • Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology, PubMed
  • Liver Injury from Nonsteroidal Anti-inflammatory Drugs in the United States, PubMed
  • Pennsaid Prescribing Information, PubMed
  • Topical NSAIDs for acute musculoskeletal pain in adults,
  • Voltaren Gel Prescribing Information, AccessFDA
  • Topical nonsteroidal anti-inflammatory drugs for management of osteoarthritis in long-term care patients, PubMed

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at! You can also connect with Dr. Brian Staiger on LinkedIn.

Recent Questions