Maty's Children's Nighttime Cough Syrup With Genexa Kids Allergy
In our latest question and answer, our pharmacist discusses whether or not combining Maty's Children's Nighttime Cough Syrup With Genexa Kids Allergy is safe.

Question
Is there an interaction between Matys Nighttime Cough Syrup for kids and Genexa Kids Allergy medicine?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Mar 26, 2025
Key points
- Maty's Nighttime Cough Syrup contains several herbal ingredients while Genexa Kids' Allergy contains diphenhydramine (commonly known as the active ingredient in Benadryl).
- There is no data to suggest any clinically significant interaction between Maty's Nighttime Cough Syrup and Genexa Kids' Allergy but both are likely to cause sedation or drowsiness. Using them together could enhance this effect.
Answer
Thanks for reaching out! Although it can be a challenge to definitively determine whether or not herbal/natural ingredients interact with over-the-counter or prescription drugs due to the lack of available data, there is nothing to suggest that Maty's Nighttime Cough Syrup interacts with Genexa Kids Allergy.
Combining both will likely cough more sedation than either used alone since they both contain sedating ingredients, but aside from that, they are most likely safe to use together.
In the next sections, I go into the ingredients of each of these products.
What Is In Maty's Nighttime Cough Syrup?
Maty's Nighttime Cough Syrup contains the following ingredients:
- Honey Blend (Clover, Buckwheat)
- Elderberry Fruit Extract
- Aronia Berry
- Acerola Cherry Extract
- Chamomile Leaves
- Apple Cider Vinegar
- Water
- Sea Salt
- Lemon Balm Leaf Extract
- Nutmeg Seed
- Zinc Gluconate
- Citric Acid
- Apricot Pit Extract
There is certainly some evidence that some of these ingredients (such as elderberry and nutmeg) may interact with traditional drugs, but they are used in this product in low amounts and, overall, they are all generally considered safe to take.
What Is In Genexa Kids Allergy?
Genexa, as a brand, markets 'clean' products as they strive to avoid containing artificial ingredients, dyes, or other 'fillers'. Most Genexa products, do, however, use common drugs, such as acetaminophen (generic of Tylenol) and calcium carbonate (generic of Tums).
Genexa Kids' Allergy is a product that contains diphenhydramine, which is the active ingredient in Benadryl. In addition to the active ingredient of diphenhydramine, this product contains:
- Organic agave syrup
- Natural citrus extract
- Purified water
Diphenhydramine is a sedating antihistamine and a very common ingredient in nighttime cough/cold and allergy medications. There is plenty of data available regarding what drugs it interacts with.
While there is no specific interaction between the diphenhydramine contained in Genexa Kids' Allergy and the herbal ingredients in Maty's Nighttime Cough Syrup, both will cause sedation.
Diphenhydramine is well known to be quite sedating, which is why it is often used as a sleep aid. Maty's Nighttime Cough Syrup contains several ingredients intended to cause sedation, such as lemon balm extract and chamomile.
So, if you combine Genexa Kids Allergy with Maty's Nighttime Cough Syrup, expect your child to experience drowsiness and sedation. Aside from that, there is no data to suggest any drug interactions.
Final Words
Thanks for reaching out and I hope your child starts to feel better soon.
References
- Diphenhydramine Monograph, PubChem
- Genexa Kids Allergy Product Page, Genexa
- Maty's Nighttime Cough Syrup Product Page, Maty's Health
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Dr. Brian Staiger, PharmD
- 579 views