Mucinex With Azithromycin - Interaction Details

In our latest question and answer, our pharmacist discusses whether or not there is a drug interaction between Mucinex and a Z-Pack (azithromycin).

Question

I was prescribed a Zpack for my infection. I have a lot of mucus in my chest. Can I take Mucinex?

Asked by Chase On Oct 21, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Oct 21, 2022
Last updated Apr 20, 2024

Key points

  • There is no known drug interaction between Mucinex (guaifenesin) and a Z-Pack (azithromycin)

Answer

There is no known drug interaction between azithromycin and Mucinex (guaifenesin). They are considered safe to take together.

In fact, Mucinex can be a great medication choice to help clear up the symptoms you are experiencing (chest congestion, excess mucus etc.,). While azithromycin is a commonly used antibiotic for a number of indications, when it is prescribed as a Z-pack (which contains a 5-day course of azithromycin), it is often for things like bronchitis and sinusitis.

These conditions tend to cause inflammation, chest congestion and excess mucus. Mucinex is a safe choice to use and can help with these symptoms.

Dextromethorphan, a cough suppressant and a drug commonly found in products with guaifenesin (e.g. Mucinex DM, Robitussin DM), is also safe to take with azithromycin.

About Mucinex

Guaifenesin is used to relieve chest congestion. It is in a class of medications called expectorants and works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways.

About Azithromycin

Azithromycin is used to treat certain bacterial infections, such as bronchitis; pneumonia; sexually transmitted diseases (STD); and infections of the ears, lungs, sinuses, skin, throat, and reproductive organs. It is in a class of medications called macrolide antibiotics and works by stopping the growth of bacteria.

Final Words

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References

  • Guaifenesin Monograph, PubMed
  • Azithromycin Monograph, PubMed

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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