Puravive Drug Interaction Question
In our latest question and answer, the pharmacist addresses an individual's concerns about combining the supplement Puravive with their medications.
Question
I take topiramate 100mg twice a day for epilepsy, which has been controlled for almost 20 years. I also take Metadate CD 30 mg per day for a sleep disorder, escitalopram oxalate (Lexapro) 5 mg per day for depression/anxiety, and Zyrtec 10 mg per day for allergies. I was wondering if the Puravive weight loss supplement is okay to take with these medications or if it has any interactions that could be problematic. The ingredients in Puravive include luteolin (Perilla frutescens), kudzu (Pueraria lobata), holy basil (Ocimum sanctum), white Korean ginseng (Panax ginseng), amur cork bark (Phellodendron amurense), propolis (propolis), quercetin (quercetum), and oleuropein (Olea europaea). Thank you for your help!
Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated May 07, 2024
Key points
- Puravive is a dietary supplement marketed to help support weight loss. It contains several herbal ingredients, such as Luteolin, Kudzu Root Extract, Holy Basil, White Korean Ginseng (Panax ginseng), Propolis, Quercetin and Oleuropein.
- Puravive contains several different herbal ingredients, and has the potential to interact with some over-the-counter and prescription drugs.
- Be sure to use our drug-herbal interaction checker to look up potentiation interactions, and as always, speak with your doctor before making changes to your medication regimen.
Answer
Thanks for reaching out!
While we did not have the dietary supplement 'Puravive' listed in our drug-herbal interaction checker, we have added it after receiving your question so you can check for interactions. You can check it out here.
Puravive contains several different herbal ingredients, so it is important to take them all into consideration when looking into potential drug interactions. The supplement contains the following:
- Luteolin
- Kudzu Root Extract
- Holy Basil
- White Korean Ginseng (Panax ginseng)
- Propolis
- Quercetin
- Oleuropein
It also contains several inactive ingredients.
Due to the numerous herbals in Puravive, we have a large number of theoretical interactions listed (our interaction checker documents over 1,000 possible interactions!).
However, when we checked the drugs you mentioned in your question (Zyrtec, topiramate, Lexapro, Metadate CD), only one theoretical interaction was reported. You can see the interaction report here.
The reported interaction, between the Panax ginseng in Puravive and methylphenidate, is a minor one and unlikely to have clinically significant effects.
The interaction is as follows:
- Methylphenidate is a stimulant drug, and ginseng has been reported in some studies to have a stimulant effect. Theoretically, ginseng could potentiate the effects of methylphenidate. However, this has not been specifically reported in humans, and it is unlikely the interaction would result in clinically significant effects.
All the other ingredients in Puravive (Luteolin, Kudzu Root Extract, Holy Basil, White Korean Ginseng (Panax ginseng), Propolis, Quercetin, Oleuropein) returned no results when checked against Zyrtec, topiramate, Lexapro, Metadate CD.
Other Comments
It is important to emphasize that interaction studies between natural medications and drugs are generally lacking. Therefore, it is difficult to determine if the interaction listed above is the only one that could potentially occur.
Nevertheless, based on the known mechanisms of the natural medications and drugs in question, significant interactions are unlikely to occur.
As always, be sure to speak with your doctor before making any changes to your medication regimen or before you take any over-the-counter supplements so you can be appropriately monitored.
Final Words
Thanks for reaching out! I hope this answer helped.
Be sure to check out our drug-herbal interaction checker to check your drugs with over 1,000 natural medicines. If you have any specific questions about a supplement, feel free to contact us, and we can add it to our database.
References
- Electrocardiographic and hemodynamic effects of Panax ginseng, PubMed
- Efficacy and safety of the standardised Ginseng extract G115 for potentiating vaccination against the influenza syndrome and protection against the common cold [corrected], PubMed
- Electrocardiographic and blood pressure effects of energy drinks and Panax ginseng in healthy volunteers: A randomized clinical trial, PubMed
- Dr. Brian Staiger, PharmD
- 1454 views