Robitussin DM With Eliquis Interaction

There is no known drug interaction between Eliquis and Robitussin DM.


Can I take Robitussin DM for cough and chest congestion while on Eliquis?

Asked by Leo On Oct 29, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Oct 29, 2022
Last updated Dec 07, 2023

Key points

  • There is no known interaction between Robitussin DM and Eliquis. They are considered safe to use together.


There is no known drug interaction between Eliquis (Apixaban) and Robitussin DM (guaifenesin; dextromethorphan). They are considered safe to take together.

Eliquis OTC Interactions

Checking into potential drug interaction between prescription and 'over the counter' (OTC) cough/cold medications is always a good idea, especially when one of the medications is a blood thinner, like Eliquis.

For example, it is recommended to avoid several OTC pain relievers if you take Eliquis, including Advil (ibuprofen) and Aleve (naproxen). The combination of these drugs can significantly increase the risk of bleeds.

Neither guaifenesin, an expectorant, nor dextromethorphan, a cough suppressant, are thought to affect bleeding risk at all. They are considered safe with Eliquis (and other blood thinners for that matter, like warfarin).

One of the benefits of Eliquis over traditional anticoagulants (e.g. warfarin), is that it has more predictable effects and has but a fraction of the numerous food and drug interactions you need to be concerned about.

Always Ask Your Doctor Or Pharmacist Before Combining Eliquis With OTC Medications

While Eliquis is safe with Robitussin DM, below is a list of OTC medications you should not take with it until speaking with your doctor:

  • Aspirin
  • Excedrin
  • Advil (ibuprofen)
  • Aleve (naproxen)
  • Pepto-Bismol
  • MSM (methylsulfonylmethane)
  • Cod liver oil
  • Collagenase
  • Fish oil
  • Garlic
  • Ginger
  • Gingko
  • Grapefruit juice
  • Green tea
  • Guarana
  • Alli (Orlistat)
  • St. John's Wort

All of the above could potentially increase bleeding risk with Eliquis. As mentioned, however, Robitussin DM is not known to interact with it and is considered safe to take.

Final Words

Thanks so much for reaching out and I hope you found this helpful.

Additional Informaiton

More information about Eliquis can be found here:

You can always ask our pharmacists a question directly as well.


  • Eliquis Prescribing Information, BMS
  • Apixaban Monograph, PubChem

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