Taking Methylprednisolone With Advil (Ibuprofen) Or Aleve (Naproxen)

Answer

While they generally should not be taken at the same time due to possible serious additive GI effects, Advil (ibuprofen) or Aleve (naproxen) may be taken after a normal course of methylprednisolone has been completed.

Ideally, you should wait between 6 to 8 hours before taking Advil or Aleve after finishing methylprednisolone to avoid additive GI side effects.

It is important to note that there are cases where an NSAID, like Aleve or Advil, may be your best treatment option and recommended by your doctor, even if you are already taking methylprednisolone.

The risk of gastrointestinal side effects is far greater with long-term use of both drugs, and short-term use may be safe, with only a small added risk of things like nausea and cramping.

How Long To Wait

Methylprednisolone does have a long half-life (around 18-36) hours and will last in the body for 4 to 7 days after finishing your course of therapy. Nevertheless, peak effects of methylprednisolone occur within a few hours after taking it by mouth and the risk of additive GI effects significantly decreases a few hours after your last dose.

If you can avoid taking both together, I would do so, but, again, if your doctor recommends taking both, it is generally safe for the short term. I would take the medications with food however to help mitigate side effects.

About Advil And Aleve

Advil (Ibuprofen) and Aleve (naproxen) are non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs are most commonly used to treat pain, arthritis, and inflammation. NSAIDs should be administered with food or milk to help prevent gastrointestinal irritation. Common side effects associated with taking NSAIDs include but are not limited to:

• Dyspepsia
• Heartburn
• Vomiting
• Diarrhea

About Methylprednisolone

Methylprednisolone is a corticosteroid used to treat a wide variety of conditions. It can be used for its anti-inflammatory, hormone-modifying, and/or immunosuppressive effects.

In general, methylprednisolone should be given with a meal and in the morning although more specific dosing schedules are often given when using an oral steroid. Common side effects associated with taking methylprednisolone include but are not limited to:

• Anxiety
• GI irritation
• Insomnia
• Diarrhea
• Hypertension

Final Words

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