Taking Mucinex DM & Delsym Together
Our pharmacist answers the latest question regarding whether or not it is okay to take Mucinex DM and Delsym Together.

Question
Is it OK to take Mucinex DM and Delsym together?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 14, 2025
Key points
- Mucinex DM and Delsym share a common ingredient (dextromethorphan) and should not be taken together.
Answer
You should not take Delsym along with Mucinex DM as they both contain the same ingredient (dextromethorphan). Combining these products would be considered a 'therapeutic duplication'.
Delsym contains the cough suppressant dextromethorphan.
Mucinex DM contains two drugs, dextromethorphan, and the expectorant, guaifenesin.
Taking both would result in taking a double dose of the dextromethorphan, which could increase the risk of side effects occurring.
You certainly need to be careful when taking multiple over-the-counter medications as many of them share the same ingredients.
The two drugs in question here are a great example of this. Dextromethorphan and guaifenesin are very common ingredients in cold/cold medications which is why it is important to always read the labels of products you are considering taking.
You can simply take Mucinex DM at the recommended dosages to get both an expectorant (guaifenesin) and a cough suppressant (dextromethorphan).
Robitussin DM is an alternative option that also contains guaifenesin and dextromethorphan.
Final Words
I hope you found this answer helpful! Reach back out anytime.
References
- Guaifenesin Monograph, PubChem
- Dextromethorphan Monograph, PubChem
- Mucinex Manufacturer Website, Mucinex.com
- Delsym Manufacturer Website, Delsym.com
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Dr. Brian Staiger, PharmD
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